天然产品,PGC - 1 α,和杜氏肌营养不良症.
关键词: AAV, adeno-associated virus AMP, adenosine monophosphate AMPK, 5′ adenosine monophosphate-activated protein kinase ASO, antisense oligonucleotides ATF2, activating transcription factor 2 ATP, adenosine triphosphate BMD, Becker muscular dystrophy COPD, chronic obstructive pulmonary disease CREB, cyclic AMP response element-binding protein CnA, calcineurin a DAGC, dystrophin-associated glycoprotein complex DGC, dystrophin–glycoprotein complex DMD, Duchenne muscular dystrophy DRP1, dynamin-related protein 1 DS, Down syndrome ECM, extracellular matrix EGCG, epigallocatechin-3-gallate ERRα, estrogen-related receptor alpha FDA, U. S. Food and Drug Administration FGF, fibroblast growth factor FOXO1, forkhead box class-O1 GABP, GA-binding protein GPX, glutathione peroxidase GSK3b, glycogen synthase kinase 3b HCT, hydrochlorothiazide HDAC, histone deacetylase HIF-1α, hypoxia-inducible factors IL, interleukin LDH, lactate dehydrogenase MCP-1, monocyte chemoattractant protein-1 MD, muscular dystrophy MEF2, myocyte enhancer factor 2 MSCs, mesenchymal stem cells Mitochondrial oxidative phosphorylation Muscular dystrophy MyoD, myogenic differentiation NADPH, nicotinamide adenine dinucleotide phosphate NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells NMJ, neuromuscular junctions NO, nitric oxide NOS, NO synthase Natural product PDGF, platelet derived growth factor PGC-1, peroxisome proliferator-activated receptor γ coactivator 1 PPARγ activation PPARγ, peroxisome proliferator-activated receptor γ Peroxisome proliferator-activated receptor γ coactivator 1α ROS, reactive oxygen species Reactive oxygen species SIRT1, silent mating type information regulation 2 homolog 1 SOD, superoxide dismutase SPP1, secreted phosphoprotein 1 TNF-α, tumor necrosis factor-α UCP, uncoupling protein VEGF, vascular endothelial growth factor cGMP, cyclic guanosine monophosphate iPSCs, induced pluripotent stem cells p38 MAPK, p38 mitogen-activated protein kinase
来 源:
DOI:10.1016/j.apsb.2020.01.001
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