表观遗传策略与 PD - L1 / PD - 1 靶向癌症免疫疗法协同增强抗肿瘤反应。
关键词: 5-AzaC, 5-azacitidine ACE1, angiotensin converting enzyme ACP1, human red cell acid phosphatase APC, antigen-presenting cell BETi, bromodomain and extra-terminal motif inhibitors CCL22 (MDC), macrophage-derived chemokine CLL, chronic lymphocytic leukemia CTA, cancer testis antigen CTLA-4, cytotoxic T lymphocyte antigen 4 CTLs, cytotoxic T lymphocytes CX3CL1, C-X3-C motif chemokine ligand 1 CXCL, CXC chemokine ligand Cancer DC, dendritic cell DNMT1, DNA methyltransferase 1 DNMTi, DNA methyltransferase inhibitors EZH2, enhancer of zeste homolog 2 Epigenetic regulation FDA, U. S. Food and Drug Administration FOXP3, forkhead box P3 H3K27me3, tri-methylation of lysine 27 on histone H3 HDACi, histone deacetylase inhibitor IDO, indoleamine 2,3-dioxygenase IFN-γ, interferon-gamma Immune cycle Immunotherapy LAG-3, lymphocyte activation gene-3 MDSCs, myeloid-derived suppressor cells MHC, major histocompatibility complex OS, overall survival PD-1, programmed cell death 1 PD-L1, programmed cell death ligand 1 PD-L1/PD-1 blockade PRC2, polycomb repressive complex 2 TAA, tumor-associated antigen TET2, ten-eleven translocation 2 TH-1, T helper type 1 TIL, tumor infiltrating lymphocytes TIM-3, T cell immunoglobulin and mucin domain 3 Tregs, regulatory T cells UHRF1, ubiquitin-like PHD and RING finger domain-containing 1
来 源: DOI:10.1016/j.apsb.2019.09.006 PDF(Sci-hub) PDF(Pubmed)