关键词： ADAMTS9, A disintegrin and metalloproteinase with thrombospondin motifs 9 AHR, Aryl Hydrocarbon Receptor AMPK, Adenosine Monophosphate-activated protein kinase ARRB1, Arrestin beta 1 Ag, Silver Al2O3, Aluminium oxide Au, Gold Aβ, Amyloid Beta BCB, Blood-cerebrospinal fluid barrier BNIP3−3, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 BaP, Benzo[a]pyrene Biomarkers CCNB1, Cyclin B1 CDC25A, M-phase inducer phosphatase 1 CDC25C, M-phase inducer phosphatase 3 CDK, Cyclin-dependent Kinase CDK1, Cyclin-dependent kinase 1 CDK6, Cyclin-dependent kinase 6 CDKN1b, Cyclin-dependent kinase Inhibitor 1B CEC, Contaminants of Emerging Concern COPD, Chronic obstructive pulmonary disease COX2, Cyclooxygenase-2 CTGF, Connective Tissue Growth Factor DGCR8, DiGeorge syndrome chromosomal [or critical] region 8 DNA, Deoxy ribonucleic acid DON, Deoxynivalenol ER, Endoplasmic Reticulum Environment Epigenetics Fadd, Fas-associated protein with death domain GTP, Guanosine triphosphate Gene regulation Grp78/BIP, Binding immunoglobulin protein HSPA1A, Heat shock 70 kDa protein 1 Hpf, Hours post fertilization IL-6, Interleukin 6 IL1R1, Interleukin 1 receptor, type 1 LIN28B, Lin-28 homolog B LRP-1-, Low density lipoprotein receptor-related protein 1 MAPK, Mitogen Activated Protein Kinase MC-LR, Microcystin-Leucine Arginine MC-RR, Microcystin-Arginine Arginine MRE, MicroRNA Response Elements Mn, Manganese NASH, Non-alcoholic steatohepatitis NET1, Neuroepithelial Cell Transforming 1 NF- ҡB, Nuclear Factor kappa-light-chain-enhancer of activated B cells NFKBAP, NFKB Activating protein-1 NMDAR, N-methyl-d-aspartate receptor NPs, Nanoparticles Non-coding RNAs Nrf2, Nuclear factor erythroid 2-related factor 2 PDCD4, Programmed cell death protein 4 PFAS, Poly-fluoroalkyl substances PM2.5, Particulate Matter2.5 RISC, RNA-induced silencing complex RNA, Ribonucleic acid RNAi, RNA interference RNase III, Ribonuclease III SEMA6D, Semaphorin-6D SOLiD, Sequencing by Oligonucleotide Ligation and Detection SPIONs, Superparamagnetic Iron Oxide Nanoparticles SiO2, Silicon dioxide TCDD, 2,3,7,8-Tetrachlorodibenzodioxin TNF-α, Tumor necrosis factor – alpha TP53, Tumor protein 53 TRBP, Transactivation Response RNA Binding Protein Toxicity UTR, Untranslated region WHO, World Health Organization Wnt, Wingless-related integration site ZEA, Zearalanone Zn, Zinc bcl2l11, B-cell lymphoma-2-like protein 11 ceRNA, Competing endogenous RNA lncRNAs, Long non-coding RNA mRNA, Messenger RNA miRNA, MicroRNA qRT-PCR, quantitative Real Time-Polymerase Chain Reaction ripk 1, Receptor-interacting serine/threonine-protein kinase 1

来  源：   DOI：10.1016/j.toxrep.2020.04.010   PDF(Sci-hub)   PDF(Pubmed)

Abstract：
The advent of new technologies has paved the rise of various chemicals that are being employed in industrial as well as consumer products. This leads to the accumulation of these xenobiotic compounds in the environment where they pose a serious threat to both target and non-target species. miRNAs are one of the key epigenetic mechanisms that have been associated with toxicity by modulating the gene expression post-transcriptionally. Here, we provide a comprehensive view on miRNA biogenesis, their mechanism of action and, their possible role in xenobiotic toxicity. Further, we review the recent in vitro and in vivo studies involved in xenobiotic exposure induced miRNA alterations and the mRNA-miRNA interactions. Finally, we address the challenges associated with the miRNAs in toxicological studies.
摘要：
新技术的出现为工业和消费品中使用的各种化学品的兴起铺平了道路。这导致这些异源生物化合物在环境中的积累,其中它们对目标和非目标物种都构成严重威胁。miRNA是通过转录后调节基因表达与毒性相关的关键表观遗传机制之一。这里,我们提供了关于miRNA生物发生的全面观点，他们的作用机制，它们在异种生物毒性中的可能作用。Further,我们回顾了最近的体外和体内研究，涉及异种生物暴露诱导的miRNA改变和mRNA-miRNA相互作用。最后,我们解决了毒理学研究中与miRNA相关的挑战。
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