关键词： BRAF mutation DNA mismatch repair deficiency PD-1 inhibitors advanced colorectal cancer high microsatellite instability immunotherapy

Mesh ： Abdominal Neoplasms / drug therapy genetics secondary Adenocarcinoma / drug therapy genetics secondary Aged Antibodies, Monoclonal, Humanized / therapeutic use Biomarkers, Tumor / genetics Colorectal Neoplasms / drug therapy genetics pathology DNA Mismatch Repair / genetics Female Humans Immune Checkpoint Inhibitors / therapeutic use Immunotherapy Microsatellite Instability Mutation Pelvic Neoplasms / drug therapy genetics secondary Proto-Oncogene Proteins B-raf / genetics Treatment Outcome

来  源：   DOI：10.2217/imt-2019-0148   PDF(Sci-hub)

Abstract：
Metastatic colorectal cancer with BRAF mutation is a type of highly invasive malignant tumor with poor prognosis and few treatment options. Here, we report a case of a BRAF-mutant and DNA mismatch-repair deficiency colorectal cancer patient with postoperative recurrence as well as abdominal cavity and pelvic metastasis, whose condition was relieved continuously after treatment with a new anti-PD-1 antibody, BGB-A317.
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