关键词: BRAF mutation DNA mismatch repair deficiency PD-1 inhibitors advanced colorectal cancer high microsatellite instability immunotherapy
Mesh : Abdominal Neoplasms / drug therapy genetics secondary Adenocarcinoma / drug therapy genetics secondary Aged Antibodies, Monoclonal, Humanized / therapeutic use Biomarkers, Tumor / genetics Colorectal Neoplasms / drug therapy genetics pathology DNA Mismatch Repair / genetics Female Humans Immune Checkpoint Inhibitors / therapeutic use Immunotherapy Microsatellite Instability Mutation Pelvic Neoplasms / drug therapy genetics secondary Proto-Oncogene Proteins B-raf / genetics Treatment Outcome
来 源:
DOI:10.2217/imt-2019-0148
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