METHODS: Meta-analysis of studies identified through search in the PubMed, Embase, LILACS, and Cochrane Library databases, on February 19, 2019.
METHODS: A total of 748 articles were identified, 29 of which were relevant to the objectives of this study. The prevalence of vitamin D deficiency found was 0.32 (95% CI=0.25-0.41; I2=92%, p<0.01). In the subgroup analyses, the most significant results were observed in the group of patients using cytochrome P450-inducing antiepileptic drugs, with a prevalence of 0.33 (95% CI=0.21-0.47; I2=86%, p<0.01) and, considering the study design, in the subgroup of cohort studies, with a prevalence of 0.52 (95% CI=0.40-0.64; I2=76%, p<0.01).
CONCLUSIONS: Taking into account the deleterious effects of vitamin D deficiency on the bone health of individuals using antiepileptic drugs, it is suggested to include in their care 25-hydroxyvitamin D monitoring, cholecalciferol supplementation, and treatment of the deficiency, when present.
方法:通过PubMed搜索确定的研究的荟萃分析,Embase,LILACS,和Cochrane图书馆数据库,2019年2月19日。
方法:共确定了748篇文章,其中29个与本研究的目标相关。发现维生素D缺乏的患病率为0.32(95%CI=0.25-0.41;I2=92%,p<0.01)。在亚组分析中,在使用细胞色素P450诱导抗癫痫药物的患者组中观察到最显著的结果,患病率为0.33(95%CI=0.21-0.47;I2=86%,p<0.01)和,考虑到研究设计,在队列研究的亚组中,患病率为0.52(95%CI=0.40-0.64;I2=76%,p<0.01)。
结论:考虑到维生素D缺乏对使用抗癫痫药物的个体骨骼健康的有害影响,建议在他们的护理中包括25-羟基维生素D监测,补充胆钙化醇,和治疗缺陷,当存在。