{Reference Type}: Journal Article
{Title}: Vitamin D deficiency in pediatric patients using antiepileptic drugs: systematic review with meta-analysis.
{Author}: Junges C;Machado TD;Nunes Filho PRS;Riesgo R;Mello ED;
{Journal}: J Pediatr (Rio J)
{Volume}: 96
{Issue}: 5
{Year}: Sep 2020 0
{Factor}: 2.99
{DOI}: 10.1016/j.jped.2020.01.004
{Abstract}: <B>OBJECTIVE: </B>To measure the prevalence of vitamin D deficiency (through the 25-hydroxyvitamin D metabolite) in pediatric patients using antiepileptic drugs.<BR><B>METHODS: </B>Meta-analysis of studies identified through search in the PubMed, Embase, LILACS, and Cochrane Library databases, on February 19, 2019.<BR><B>METHODS: </B>A total of 748 articles were identified, 29 of which were relevant to the objectives of this study. The prevalence of vitamin D deficiency found was 0.32 (95% CI=0.25-0.41; I2=92%, p<0.01). In the subgroup analyses, the most significant results were observed in the group of patients using cytochrome P450-inducing antiepileptic drugs, with a prevalence of 0.33 (95% CI=0.21-0.47; I2=86%, p<0.01) and, considering the study design, in the subgroup of cohort studies, with a prevalence of 0.52 (95% CI=0.40-0.64; I2=76%, p<0.01).<BR><B>CONCLUSIONS: </B>Taking into account the deleterious effects of vitamin D deficiency on the bone health of individuals using antiepileptic drugs, it is suggested to include in their care 25-hydroxyvitamin D monitoring, cholecalciferol supplementation, and treatment of the deficiency, when present.