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Abstract：
BACKGROUND: Several case-control studies have been performed to investigate the association between 894 G > T polymorphism in endothelial nitric oxide synthase (eNOS) gene and susceptibility to preeclampsia. However, the results were inconsistent and inconclusive. Therefore, we conducted this meta-analysis to investigate the association. Methods: All studies published up to September 30, 2019 were identified by searching electronic databases such as PubMed, EMBASE, CNKI, and WANFANG. Results: A total of 35 case- control studies with 4,254 cases and 5,801 controls were selected. There was a significant association between the eNOS 894 G > T and preeclampsia risk. When stratified by ethnicity, an increased risk of preeclampsia was found in Caucasian and Mixed populations, but not in Asians or Africans. Conclusion: Based on our meta-analysis, the eNOS 894 G > T polymorphism was associated with an increased risk of preeclampsia, especially among Caucasian and Mixed populations.
摘要：
背景：已经进行了一些病例对照研究，以研究内皮型一氧化氮合酶（eNOS）基因894G>T多态性与先兆子痫易感性之间的关系。然而,结果不一致且无定论.因此,我们进行了这项荟萃分析来调查这种关联.方法：截至2019年9月30日发表的所有研究都是通过搜索PubMed等电子数据库来确定的，EMBASE,CNKI,和万方。结果：共选择35项病例对照研究，其中4,254例和5,801例对照。eNOS894G>T与先兆子痫风险之间存在显著关联。当按种族分层时，在高加索人和混合人群中发现先兆子痫的风险增加，但不是亚洲人或非洲人。结论：根据我们的荟萃分析，eNOS894G>T多态性与先兆子痫的风险增加有关，尤其是在高加索和混合人群中。
