%0 Journal Article
%T Association of Endothelial Nitric Oxide Synthase 894G > T Polymorphism with Preeclampsia Risk: A Systematic Review and Meta-Analysis based on 35 Studies.
%A Abbasi H
%A Dastgheib SA
%A Hadadan A
%A Karimi-Zarchi M
%A Javaheri A
%A Meibodi B
%A Zanbagh L
%A Tabatabaei RS
%A Neamatzadeh H
%J Fetal Pediatr Pathol
%V 40
%N 5
%D Oct 2021
%M 31920131
%F 1.412
%R 10.1080/15513815.2019.1710880
%X <B>BACKGROUND: </B>Several case-control studies have been performed to investigate the association between 894 G > T polymorphism in endothelial nitric oxide synthase (eNOS) gene and susceptibility to preeclampsia. However, the results were inconsistent and inconclusive. Therefore, we conducted this meta-analysis to investigate the association. Methods: All studies published up to September 30, 2019 were identified by searching electronic databases such as PubMed, EMBASE, CNKI, and WANFANG. Results: A total of 35 case- control studies with 4,254 cases and 5,801 controls were selected. There was a significant association between the eNOS 894 G > T and preeclampsia risk. When stratified by ethnicity, an increased risk of preeclampsia was found in Caucasian and Mixed populations, but not in Asians or Africans. Conclusion: Based on our meta-analysis, the eNOS 894 G > T polymorphism was associated with an increased risk of preeclampsia, especially among Caucasian and Mixed populations.