{Reference Type}: Journal Article
{Title}: Association of Endothelial Nitric Oxide Synthase 894G > T Polymorphism with Preeclampsia Risk: A Systematic Review and Meta-Analysis based on 35 Studies.
{Author}: Abbasi H;Dastgheib SA;Hadadan A;Karimi-Zarchi M;Javaheri A;Meibodi B;Zanbagh L;Tabatabaei RS;Neamatzadeh H;
{Journal}: Fetal Pediatr Pathol
{Volume}: 40
{Issue}: 5
{Year}: Oct 2021
{Factor}: 1.412
{DOI}: 10.1080/15513815.2019.1710880
{Abstract}: <B>BACKGROUND: </B>Several case-control studies have been performed to investigate the association between 894 G > T polymorphism in endothelial nitric oxide synthase (eNOS) gene and susceptibility to preeclampsia. However, the results were inconsistent and inconclusive. Therefore, we conducted this meta-analysis to investigate the association. Methods: All studies published up to September 30, 2019 were identified by searching electronic databases such as PubMed, EMBASE, CNKI, and WANFANG. Results: A total of 35 case- control studies with 4,254 cases and 5,801 controls were selected. There was a significant association between the eNOS 894 G > T and preeclampsia risk. When stratified by ethnicity, an increased risk of preeclampsia was found in Caucasian and Mixed populations, but not in Asians or Africans. Conclusion: Based on our meta-analysis, the eNOS 894 G > T polymorphism was associated with an increased risk of preeclampsia, especially among Caucasian and Mixed populations.