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Abstract：
BACKGROUND: To investigate whether chronic adherence to the French Nutrition and Health Program (PNNS) guidelines was associated with better cardiovascular health.
METHODS: A study nested within the SU.VI.MAX2 cohort was conducted on participants without cardiovascular risk factors. Long-term adherence to the PNNS guidelines was estimated using validated dietary scores from 2007 and 2012. Individuals who did (PNNS+) and did not (PNNS-) continuously adhere to the PNNS guidelines were included. Applanation tonometry, impedance cardiography, laser doppler flowmetry, heart rate, heart rate variability, endothelial function was used for the assessment of cardiovascular health.
RESULTS: A total of 49 subjects (mean age 65.4 ± 5.6 years, 75.5% women) had been included. Those in the PNNS+ group (n=26) were older, had a higher BMI and fat mass than those in the PNNS- group, both groups had similar metabolic parameters. After adjusting for sex, age, and BMI, PNNS+ subjects were found to have a lower heart rate (60.2 ± 8.0 vs 64.3 ± 8.4 beats/min, p=0.042), a lower heart rate × systolic blood pressure product (7166 ± 1323 vs 7788 ± 1680 beats× mmHg/min, p = 0.009), a longer diastole duration (66.7 ± 3.1% vs 64.6 ± 4.1% of the cardiac cycle duration, p=0.049), and a shorter tension-time index (2145 ± 489 vs 2307 ± 428 ms * mmHg, p=0.018) compared to the PNNS- group.
CONCLUSIONS: Long-term adherence to the PNNS guidelines had a favorable impact on heart rate, diastole duration, and myocardial oxygen consumption.
BACKGROUND: NCT01579409.
METHODS: A study nested within the SU.VI.MAX2 cohort was conducted on participants without cardiovascular risk factors. Long-term adherence to the PNNS guidelines was estimated using validated dietary scores from 2007 and 2012. Individuals who did (PNNS+) and did not (PNNS-) continuously adhere to the PNNS guidelines were included. Applanation tonometry, impedance cardiography, laser doppler flowmetry, heart rate, heart rate variability, endothelial function was used for the assessment of cardiovascular health.
RESULTS: A total of 49 subjects (mean age 65.4 ± 5.6 years, 75.5% women) had been included. Those in the PNNS+ group (n=26) were older, had a higher BMI and fat mass than those in the PNNS- group, both groups had similar metabolic parameters. After adjusting for sex, age, and BMI, PNNS+ subjects were found to have a lower heart rate (60.2 ± 8.0 vs 64.3 ± 8.4 beats/min, p=0.042), a lower heart rate × systolic blood pressure product (7166 ± 1323 vs 7788 ± 1680 beats× mmHg/min, p = 0.009), a longer diastole duration (66.7 ± 3.1% vs 64.6 ± 4.1% of the cardiac cycle duration, p=0.049), and a shorter tension-time index (2145 ± 489 vs 2307 ± 428 ms * mmHg, p=0.018) compared to the PNNS- group.
CONCLUSIONS: Long-term adherence to the PNNS guidelines had a favorable impact on heart rate, diastole duration, and myocardial oxygen consumption.
BACKGROUND: NCT01579409.
摘要：
背景：调查长期坚持法国营养与健康计划（PNNS）指南是否与更好的心血管健康相关。
方法：一项嵌套在SU内的研究。VI.MAX2队列对无心血管危险因素的参与者进行。使用2007年和2012年验证的饮食评分对PNNS指南的长期依从性进行评估。包括连续遵守PNNS指南（PNNS）和不遵守PNNS指南的个人。移植眼压测定,心阻抗描记术,激光多普勒血流仪,心率,心率变异性,内皮功能用于评估心血管健康.
结果：共有49名受试者（平均年龄65.4±5.6岁，75.5％的妇女）被包括在内。PNNS+组（n=26）年龄较大，BMI和脂肪量高于PNNS组，两组的代谢参数相似.在适应性爱之后，年龄,BMI,发现PNNS受试者的心率较低（60.2±8.0vs64.3±8.4次/分钟，p=0.042),较低的心率×收缩压乘积（7166±1323vs7788±1680次搏动×mmHg/min，p=0.009),舒张持续时间较长(66.7±3.1%vs64.6±4.1%的心动周期,p=0.049),和较短的张力时间指数（2145±489vs2307±428ms*mmHg，p=0.018）与PNNS组相比。
结论：长期遵守PNNS指南对心率有有利的影响，舒张期,和心肌耗氧量.
背景：NCT01579409。
方法：一项嵌套在SU内的研究。VI.MAX2队列对无心血管危险因素的参与者进行。使用2007年和2012年验证的饮食评分对PNNS指南的长期依从性进行评估。包括连续遵守PNNS指南（PNNS）和不遵守PNNS指南的个人。移植眼压测定,心阻抗描记术,激光多普勒血流仪,心率,心率变异性,内皮功能用于评估心血管健康.
结果：共有49名受试者（平均年龄65.4±5.6岁，75.5％的妇女）被包括在内。PNNS+组（n=26）年龄较大，BMI和脂肪量高于PNNS组，两组的代谢参数相似.在适应性爱之后，年龄,BMI,发现PNNS受试者的心率较低（60.2±8.0vs64.3±8.4次/分钟，p=0.042),较低的心率×收缩压乘积（7166±1323vs7788±1680次搏动×mmHg/min，p=0.009),舒张持续时间较长(66.7±3.1%vs64.6±4.1%的心动周期,p=0.049),和较短的张力时间指数（2145±489vs2307±428ms*mmHg，p=0.018）与PNNS组相比。
结论：长期遵守PNNS指南对心率有有利的影响，舒张期,和心肌耗氧量.
背景：NCT01579409。
