Survival outcomes of mucosal melanoma in the USA.

• 影响指数: 3.674
• 发表时间: Dec 2019
• 来源期刊: Future Oncol
• DOI: 10.2217/fon-2019-0465
• PMID: 31724885
• 文章类型: Comparative Study
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Al-Haseni A,Vrable A,Qureshi MM,Mathews S,Pollock S,Truong MT,Sahni D

关键词: gastrointestinal melanomas; genitourinary melanomas; head and neck melanomas; mucosal melanoma

Mesh: Aged; Aged, 80 and over; Female; Follow-Up Studies; Gastrointestinal Neoplasms / mortality pathology therapy; Head and Neck Neoplasms / mortality pathology therapy; Humans; Kaplan-Meier Estimate; Male; Melanoma / mortality pathology therapy; Middle Aged; Mucous Membrane / pathology; Sex Factors; Survival Rate; Treatment Outcome; United States / epidemiology; Urogenital Neoplasms / mortality pathology therapy

Abstract

Background: Mucosal melanomas (MM) arise within the lining of the gastrointestinal (GI), genitourinary (GU) and head and neck (HN) systems. Method: A retrospective analysis of the National Comprehensive Database identified 4,961 MM patients. Primary objective was to compare survival outcomes across the different locations. Results: Overall survival for GI melanomas was significantly shorter than HN and GU melanomas. Median survival (95% confidence interval) was 19.5 (18.0-21.5), 26.4 (24.9-28.3), and 43.9 (38.8-47.8), months for GI, HN and GU cases, respectively (p<0.0001). Conclusion: This is the largest study of MM in a US based population, demonstrating worse overall survival for GI MM in comparison to HN and GU melanomas.