{Reference Type}: Comparative Study {Title}: Survival outcomes of mucosal melanoma in the USA. {Author}: Al-Haseni A;Vrable A;Qureshi MM;Mathews S;Pollock S;Truong MT;Sahni D; {Journal}: Future Oncol {Volume}: 15 {Issue}: 34 {Year}: Dec 2019 {Factor}: 3.674 {DOI}: 10.2217/fon-2019-0465 {Abstract}: Background: Mucosal melanomas (MM) arise within the lining of the gastrointestinal (GI), genitourinary (GU) and head and neck (HN) systems. Method: A retrospective analysis of the National Comprehensive Database identified 4,961 MM patients. Primary objective was to compare survival outcomes across the different locations. Results: Overall survival for GI melanomas was significantly shorter than HN and GU melanomas. Median survival (95% confidence interval) was 19.5 (18.0-21.5), 26.4 (24.9-28.3), and 43.9 (38.8-47.8), months for GI, HN and GU cases, respectively (p<0.0001). Conclusion: This is the largest study of MM in a US based population, demonstrating worse overall survival for GI MM in comparison to HN and GU melanomas.