目的:近几十年来,先天性心脏病(CHD)患者的生存率有了显著提高。然而,根据国家和医疗系统的不同,存在差距。这项研究旨在使用韩国的大规模人口数据分析CHD婴儿直到18岁的存活率,并调查出生时新生儿状况的影响。
方法:我们回顾性提取了2002年1月至2020年12月的韩国国民健康保险服务索赔数据。我们纳入了年龄小于1岁的冠心病患者。随访时间是直到他们死亡或直到他们在18岁之前被审查。CHD病变按等级分类(锥形,严重的非截肢,主动脉缩窄,室间隔缺损,房间隔缺损,和其他人)。几种新生儿疾病被认为是危险因素。
结果:总体而言,127,958名婴儿被诊断患有冠心病,2,275名婴儿在18岁之前死亡。CHD患儿儿童期生存率为97.9%。儿童死亡率最高的是与非截尾畸形(19.7%)有关,其次是截尾缺损(10.2%)。儿童死亡的重要危险因素是复杂的CHD,肺动脉高压,出生窒息,小于胎龄,呼吸窘迫,肺出血,支气管肺发育不良,和抽搐。
结论:在韩国,CHD婴儿的生存率一直很好。几种新生儿疾病是儿童死亡的危险因素。个体化风险评估和最佳治疗策略可能有助于提高其生存率。
OBJECTIVE: The survival of patients with congenital heart disease (CHD) has dramatically improved over recent decades. However, a disparity exists depending on the country and medical system. This study aimed to analyze the survival of infants with CHD until the age of 18 years using large-scale population data in South Korea and investigate the effect of neonatal conditions at birth.
METHODS: We retrospectively extracted the Korean National Health Insurance Service claims data from January 2002 to December 2020. We included patients diagnosed with CHD who were less than one year of age. The follow-up duration was until their death or until they were censored before the age of 18 years. The CHD lesions were classified hierarchically (conotruncal, severe non-conotruncal, coarctation of the aorta, ventricular septal defect, atrial septal defect, and others). Several neonatal conditions were adopted as risk factors.
RESULTS: Overall, 127,958 infants had been diagnosed with CHD and 2,275 died before the age of 18 years. The survival rate of infants with CHD during childhood was 97.9%. The highest childhood mortality rate was associated with non-conotruncal defects (19.7%), followed by conotruncal defects (10.2%). The significant risk factors for childhood mortality were complex CHD, pulmonary hypertension, birth asphyxia, small for gestational age, respiratory distress, pulmonary hemorrhage, bronchopulmonary dysplasia, and convulsions.
CONCLUSIONS: The survival of infants with CHD has been favorable in South Korea. Several neonatal conditions are risk factors for childhood mortality. Individualized risk assessment and optimal treatment strategies may help improve their survival rate.