A computer-based search was performed to retrieve publications from PubMed, Cochrane library, Embase, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, and Wanfang databases using the search terms \"glucocerebrosidase\", \"Parkinson\'s disease\", and \"dementia\". After rigorous screening, cohort studies were included for meta-analysis.
The risk of PDD in GBA variant carriers was 1.94 times that in non-carriers (hazard ratio [HR], 1.94; 95% confidence interval [CI], 1.53-2.46). The risk of PDD in GBA polymorphism carriers was 1.87 times that in non-carriers (HR, 1.87; 95% CI, 1.18-2.98). The risk of PDD in GBA mutation carriers was 3.64 times that in non-carriers (HR, 3.64; 95% CI, 2.74-4.83). The risk of PDD in p.L444P variant carriers (HR, 4.81; 95% CI, 3.37-6.86) was significantly higher than that in p.N370S variant carriers (HR, 1.95; 95% CI, 1.29-1.94).
GBA polymorphisms and mutations are potential risk factors for PDD.