Prostacyclin Analogue-Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats.

• 影响指数: 9.531
• 发表时间: Jun 2019
• 来源期刊: JACC Basic Transl Sci
• DOI: 10.1016/j.jacbts.2018.12.006
• PMID: 31312756
• 文章类型: Journal Article
• 作者列表: Yajima S,Miyagawa S,Fukushima S,Sakai Y,Iseoka H,Harada A,Isohashi K,Horitsugi G,Mori Y,Shiozaki M,Ohkawara H,Sakaniwa R,Hatazawa J,Yoshioka Y,Sawa Y

关键词: ANG, angiopoietin; EPR, enhanced permeability and retention; I/R, ischemia/reperfusion; IL, interleukin; MBF, myocardial blood flow; MRI, magnetic resonance imaging; NP, nanoparticle; ONO-1301; PET, positron emission tomography; PMNL, polymorphonuclear leukocyte; VEGF, vascular endothelial growth factor; ischemia/reperfusion injury; nanoparticles; prostacyclin

Abstract

Intravenously injected ONO-1301-containing nanoparticles (ONO-1301NPs), unlike an ONO-1301 solution, selectively accumulated in the ischemia/reperfusion (I/R)-injured myocardium of rats and contributed to the prolonged retention of ONO-1301 in the targeted myocardial tissue. In the ischemic area, proangiogenic cytokines were up-regulated and inflammatory cytokines were down-regulated upon ONO-1301NP administration. Consequently, ONO-1301NP-injected rats exhibited a smaller infarct size, better-preserved capillary networks, and a better-preserved myocardial blood flow at 24 h after I/R injury, compared with those in vehicle-injected or ONO-1301 solution-injected rats. ONO-1301NPs attenuate the myocardial I/R injury via proangiogenic and anti-inflammatory effects of the drug.