%0 Journal Article
%T Prostacyclin Analogue-Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats.
%A Yajima S
%A Miyagawa S
%A Fukushima S
%A Sakai Y
%A Iseoka H
%A Harada A
%A Isohashi K
%A Horitsugi G
%A Mori Y
%A Shiozaki M
%A Ohkawara H
%A Sakaniwa R
%A Hatazawa J
%A Yoshioka Y
%A Sawa Y
%J JACC Basic Transl Sci
%V 4
%N 3
%D Jun 2019
%M 31312756
%F 9.531
%R 10.1016/j.jacbts.2018.12.006
%X Intravenously injected ONO-1301-containing nanoparticles (ONO-1301NPs), unlike an ONO-1301 solution, selectively accumulated in the ischemia/reperfusion (I/R)-injured myocardium of rats and contributed to the prolonged retention of ONO-1301 in the targeted myocardial tissue. In the ischemic area, proangiogenic cytokines were up-regulated and inflammatory cytokines were down-regulated upon ONO-1301NP administration. Consequently, ONO-1301NP-injected rats exhibited a smaller infarct size, better-preserved capillary networks, and a better-preserved myocardial blood flow at 24 h after I/R injury, compared with those in vehicle-injected or ONO-1301 solution-injected rats. ONO-1301NPs attenuate the myocardial I/R injury via proangiogenic and anti-inflammatory effects of the drug.