{Reference Type}: Journal Article
{Title}: Prostacyclin Analogue-Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats.
{Author}: Yajima S;Miyagawa S;Fukushima S;Sakai Y;Iseoka H;Harada A;Isohashi K;Horitsugi G;Mori Y;Shiozaki M;Ohkawara H;Sakaniwa R;Hatazawa J;Yoshioka Y;Sawa Y;
{Journal}: JACC Basic Transl Sci
{Volume}: 4
{Issue}: 3
{Year}: Jun 2019
{Factor}: 9.531
{DOI}: 10.1016/j.jacbts.2018.12.006
{Abstract}: Intravenously injected ONO-1301-containing nanoparticles (ONO-1301NPs), unlike an ONO-1301 solution, selectively accumulated in the ischemia/reperfusion (I/R)-injured myocardium of rats and contributed to the prolonged retention of ONO-1301 in the targeted myocardial tissue. In the ischemic area, proangiogenic cytokines were up-regulated and inflammatory cytokines were down-regulated upon ONO-1301NP administration. Consequently, ONO-1301NP-injected rats exhibited a smaller infarct size, better-preserved capillary networks, and a better-preserved myocardial blood flow at 24 h after I/R injury, compared with those in vehicle-injected or ONO-1301 solution-injected rats. ONO-1301NPs attenuate the myocardial I/R injury via proangiogenic and anti-inflammatory effects of the drug.