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Abstract：
Health-care-associated infections (HAIs) are considered a serious public health issues that contribute substantially to the global burden of mortality and morbidity with respect to infectious diseases. The aim is to assess the burden of health-care-associated infections by collation of available data from published point prevalence surveys (PPS) on HAIs to give future guidance. Study protocol and methodology were designed according to preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines. Published research papers that conducted a point prevalence survey of HAIs in hospital settings by following the structured survey methodology employed by European Centre of Disease Prevention and Control (ECDC) were included. Of 1212 articles, 67 studies were included in the final analysis conducted across different countries. Overall, 35 studies were conducted in Europe, 21 in Asia, 9 in America, and 2 in Africa. The highest prevalence of HAIs was recorded in a study conducted in adult ICU settings of 75 regions of Europe (51.3%). The majority of the studies included HAI data on urinary tract infections, respiratory tract infections, and bloodstream infections. Klebsiella pneumonia, Pseudomonas aeruginosa and E. coli were the most frequent pathogens responsible for HAIs. PPS is an useful tool to quantify HAIs and provides a robust baseline data for policymakers. However, a standardize surveillance method is required. In order to minimize the burden of HAIs, infection prevention and control programs and antibiotic stewardship may be effective strategies to minimize the risk of HAIs.
摘要：
卫生保健相关感染（HAI）被认为是严重的公共卫生问题，对传染病的全球死亡率和发病率造成了极大的影响。目的是通过整理已发布的HAIs点患病率调查（PPS）的可用数据来评估与医疗保健相关的感染负担，以提供未来的指导。根据系统评价和荟萃分析（PRISMA）指南的首选报告项目设计研究方案和方法。包括发表的研究论文，这些论文遵循欧洲疾病预防和控制中心（ECDC）采用的结构化调查方法，对医院环境中的HAIs进行了点患病率调查。在1212篇文章中，在不同国家进行的最终分析中包括了67项研究。总的来说,在欧洲进行了35项研究，21亚洲,9在美国，2在非洲在欧洲75个地区的成人ICU环境中进行的一项研究中，HAIs的患病率最高（51.3％）。大多数研究包括尿路感染的HAI数据，呼吸道感染,和血液感染。肺炎克雷伯菌,铜绿假单胞菌和大肠杆菌是引起HAIs的最常见病原体。PPS是量化HAIs的有用工具，并为决策者提供了可靠的基线数据。然而,需要一种标准化的监测方法。为了尽量减少HAIs的负担，感染预防和控制计划以及抗生素管理可能是降低HAIs风险的有效策略。
