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Abstract：
Electroconvulsive therapy (ECT) has been suggested as a treatment for augmenting the response to clozapine in patients that do not respond well to clozapine alone and maintenance ECT (M-ECT) had also been recommended to sustain improvement. This retrospective study of up to 2 years of observation was conducted to explore whether M-ECT is beneficial for long-term maintenance of the symptom remission elicited by acute ECT. Positive and Negative Syndrome Scale (PANSS) were plotted for each patient and compared using a linear mixed-effect model. A total of thirty-eight patients were followed and classified into three groups: (1) clozapine alone (CZP, n = 15), (2) acute ECT only (A-ECT, n = 11), and (3) acute ECT with M-ECT (M-ECT, n = 12). The mean number and interval of ECT sessions during the maintenance period in the M-ECT group were 39.0 ± 26.7 and 15.6 ± 8.4 days, respectively. The slope of the M-ECT group eventually declined, but that of the A-ECT group gradually increased back to the pre-ECT level. No persistent or serious adverse effects were observed. In conclusion, A-ECT augmented the effect of clozapine, but M-ECT was required for sustaining symptom improvement.
摘要：
电惊厥疗法（ECT）已被建议作为一种治疗方法，用于增强对单独使用氯氮平反应不佳的患者对氯氮平的反应，并且还建议维持ECT（M-ECT）以维持改善。进行了长达2年的回顾性研究，以探讨M-ECT是否有利于长期维持急性ECT引起的症状缓解。绘制每位患者的阳性和阴性综合征量表（PANSS），并使用线性混合效应模型进行比较。共随访了38例患者，并分为三组：（1）单用氯氮平（CZP，n=15),（2）仅急性ECT（A-ECT，n=11),和（3）急性ECT与M-ECT（M-ECT，n=12)。M-ECT组维持期ECT疗程的平均次数和间隔时间分别为39.0±26.7和15.6±8.4天,分别。M-ECT组的斜率最终下降,但A-ECT组的水平逐渐恢复到ECT前的水平。没有观察到持续或严重的不良反应。总之,A-ECT增强了氯氮平的效果,但M-ECT是维持症状改善所必需的。
