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Abstract：
OBJECTIVE: Gene-dietary patterns may contribute to determining body composition and related biochemical indices. The aim of this study was to evaluate interactions between rs1333048 polymorphism and major dietary patterns on body fat percentage, general and central obesity, and related biochemical measurements.
METHODS: This cross-sectional study was conducted on 265 healthy Tehrani adults with mean age of 35 years (47.5% men, 52.5% women). Dietary patterns (DPs) were extracted by factor analysis. Bioelectrical impedance analysis was used for body analysis and rs1333048 was genotyped by the restriction fragment length polymorphism (PCR-RFLP) method.
RESULTS: Three DPs were extracted: restricted refined grains DP, legumes DP and healthy DP. AA genotype compared to CC genotype had greater odds for general obesity before (OR 3.14; 95% CI 1.008-9.60, P = 0.045) and after (OR 3.11; 95% CI 1.008-9.60, P = 0.048) adjusting for potential confounders. Individuals with AA genotype were more likely to be centrally obese before (OR 2.09; 95% CI 1.006-4.35, P = 0.048) and after (OR 2.63; 95% CI 1.12-6.17, P = 0.026) controlling for potential confounders. Significant interactions were observed between Legumes DP and rs1333048 SNP on waist circumference (P = 0.047), body fat % (BFP) (P = 0.048), hs-Crp (P = 0.042), BMI (P = 0.073), WHtR (P = 0.063) and odds for general obesity (P = 0.051). Following this DP reduced all these items for individuals with CC genotype, whereas increased them for people who carry CA or AA genotypes.
CONCLUSIONS: The findings indicate that there are significant associations between AA genotype of rs1333048 SNP and general and central obesity, and significant interaction between alleles of this SNP and major dietary patterns on the odds of general obesity, BFP, waist circumference, BMI, WHtR and hs-Crp.
METHODS: This cross-sectional study was conducted on 265 healthy Tehrani adults with mean age of 35 years (47.5% men, 52.5% women). Dietary patterns (DPs) were extracted by factor analysis. Bioelectrical impedance analysis was used for body analysis and rs1333048 was genotyped by the restriction fragment length polymorphism (PCR-RFLP) method.
RESULTS: Three DPs were extracted: restricted refined grains DP, legumes DP and healthy DP. AA genotype compared to CC genotype had greater odds for general obesity before (OR 3.14; 95% CI 1.008-9.60, P = 0.045) and after (OR 3.11; 95% CI 1.008-9.60, P = 0.048) adjusting for potential confounders. Individuals with AA genotype were more likely to be centrally obese before (OR 2.09; 95% CI 1.006-4.35, P = 0.048) and after (OR 2.63; 95% CI 1.12-6.17, P = 0.026) controlling for potential confounders. Significant interactions were observed between Legumes DP and rs1333048 SNP on waist circumference (P = 0.047), body fat % (BFP) (P = 0.048), hs-Crp (P = 0.042), BMI (P = 0.073), WHtR (P = 0.063) and odds for general obesity (P = 0.051). Following this DP reduced all these items for individuals with CC genotype, whereas increased them for people who carry CA or AA genotypes.
CONCLUSIONS: The findings indicate that there are significant associations between AA genotype of rs1333048 SNP and general and central obesity, and significant interaction between alleles of this SNP and major dietary patterns on the odds of general obesity, BFP, waist circumference, BMI, WHtR and hs-Crp.
摘要：
目的：基因膳食模式可能有助于确定身体成分和相关生化指标。这项研究的目的是评估rs1333048多态性和主要饮食模式对身体脂肪百分比之间的相互作用，一般和中心性肥胖，和相关的生化测量。
方法：这项横断面研究是对265名平均年龄为35岁的健康Tehrani成年人进行的（47.5％的男性，52.5%妇女）。通过因子分析提取膳食模式(DP)。生物电阻抗分析用于身体分析，并通过限制性片段长度多态性（PCR-RFLP）方法对rs1333048进行基因分型。
结果：提取了三种DP：限制精制颗粒DP，豆类DP和健康DP。与CC基因型相比，AA基因型在调整潜在混杂因素之前（OR3.14;95％CI1.008-9.60，P=0.045）和之后（OR3.11;95％CI1.008-9.60，P=0.048）出现一般肥胖的几率更大。AA基因型个体在控制潜在混杂因素之前(OR2.09;95%CI1.006-4.35,P=0.048)和之后(OR2.63;95%CI1.12-6.17,P=0.026)更有可能发生中心性肥胖。在腰围上观察到豆科植物DP和rs1333048SNP之间的显着相互作用（P=0.047），体脂百分比（BFP）（P=0.048），hs-Crp(P=0.042),BMI(P=0.073),WHtR(P=0.063)和一般肥胖的几率(P=0.051)。在这个DP减少了所有这些项目的个体与CC基因型，而对于携带CA或AA基因型的人则增加了它们。
结论：研究结果表明，rs1333048SNP的AA基因型与一般和中心性肥胖之间存在显着关联，以及该SNP的等位基因与主要饮食模式之间对一般肥胖几率的显着相互作用，BFP,腰围,BMI,WHTR和hs-Crp。
方法：这项横断面研究是对265名平均年龄为35岁的健康Tehrani成年人进行的（47.5％的男性，52.5%妇女）。通过因子分析提取膳食模式(DP)。生物电阻抗分析用于身体分析，并通过限制性片段长度多态性（PCR-RFLP）方法对rs1333048进行基因分型。
结果：提取了三种DP：限制精制颗粒DP，豆类DP和健康DP。与CC基因型相比，AA基因型在调整潜在混杂因素之前（OR3.14;95％CI1.008-9.60，P=0.045）和之后（OR3.11;95％CI1.008-9.60，P=0.048）出现一般肥胖的几率更大。AA基因型个体在控制潜在混杂因素之前(OR2.09;95%CI1.006-4.35,P=0.048)和之后(OR2.63;95%CI1.12-6.17,P=0.026)更有可能发生中心性肥胖。在腰围上观察到豆科植物DP和rs1333048SNP之间的显着相互作用（P=0.047），体脂百分比（BFP）（P=0.048），hs-Crp(P=0.042),BMI(P=0.073),WHtR(P=0.063)和一般肥胖的几率(P=0.051)。在这个DP减少了所有这些项目的个体与CC基因型，而对于携带CA或AA基因型的人则增加了它们。
结论：研究结果表明，rs1333048SNP的AA基因型与一般和中心性肥胖之间存在显着关联，以及该SNP的等位基因与主要饮食模式之间对一般肥胖几率的显着相互作用，BFP,腰围,BMI,WHTR和hs-Crp。
