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Abstract：
Parasitic diseases remain an unarguable public health problem worldwide. Liver fluke Clonorchis sinensis is a high risk pathogenic parasitic helminth which is endemic predominantly in Asian countries, including Korea, China, Taiwan, Vietnam, and the far eastern parts of Russia, and is still actively transmitted. According to the earlier 8th National Survey on the Prevalence of Intestinal Parasitic Infections in 2012, C. sinensis was revealed as the parasite with highest prevalence of 1.86% in general population among all parasite species surveyed in Korea. This fluke is now classified under one of the definite Group 1 human biological agents (carcinogens) by International Agency of Research on Cancer (IARC) along with two other parasites, Opisthorchis viverrini and Schistosoma haematobium. C. sinensis infestation is mainly linked to liver and biliary disorders, especially cholangiocarcinoma (CCA). For the purposes of this mini-review, we will only focus on C. sinensis and review pathogenesis and carcinogenesis of clonorchiasis, disease condition by C. sinensis infestation, and association between C. sinensis infestation and CCA. In this presentation, we briefly consider the current scientific status for progression of CCA by heavy C. sinensis infestation from the food-borne trematode and development of CCA. [BMB Reports 2016; 49(11): 590-597].
摘要：
寄生虫疾病仍然是世界范围内无可争议的公共卫生问题。肝吸虫是一种高风险的致病性寄生虫，主要在亚洲国家流行。包括韩国,中国,台湾,越南,和俄罗斯的远东地区，并且仍在积极传播。根据2012年较早的第8次全国肠道寄生虫感染患病率调查，在韩国调查的所有寄生虫物种中，中华寄生虫是普通人群中患病率最高的寄生虫，为1.86％。现在，这种侥幸与其他两种寄生虫一起被国际癌症研究机构（IARC）归类为确定的第1组人类生物制剂（致癌物）之一，维氏蛇头和血吸虫。C.sinensis感染主要与肝脏和胆道疾病有关，尤其是胆管癌（CCA）。就本小型审查而言，我们将只关注中华绒螯蟹，并回顾华支睾吸虫病的发病机制和致癌作用，由C.sinensis感染引起的疾病状况，以及中华念珠菌感染与CCA之间的关联。在这个演讲中,我们简要考虑了食源性吸虫引起的重C.sinensis侵染和CCA发展的当前科学状况。[BMB报告2016；49（11）：590-597]。
