Abstract：
OBJECTIVE: The study sought to alter visual spatial attention in young healthy subjects by a neuronavigated inhibitory rTMS protocol (cTBS-600) to right brain areas thought to be involved in visual attentional processes, i.e. the temporoparietal junction (TPJ) and the posterior middle frontal gyrus (pMFG), and to test the reversibility of effects by an additional consecutive cTBS to the homologue left brain cortical areas.
RESULTS: Healthy subjects showed a leftward bias of the egocentric perspective for both visual-perceptive and visual-exploratory tasks specifically for items presented in the left hemifield. cTBS to the right TPJ, and less systematically to the right pMFG reduced this bias for visuo-spatial and exploratory visuo-motor behaviour. Further, a consecutive cTBS to the left TPJ changed the bias again towards the left for a visual-perceptive task.
CONCLUSIONS: The evidence supports the notion of an involvement of the right TPJ (and pMFG) in spatial visual attention. The observations further indicate that inhibitory non-invasive brain stimulation (cTBS) to the left TPJ has a potential for reversing a rightward bias of spatial attention when the right TPJ is dysfunctional. Accordingly, the findings could have implications for therapeutic rTMS development for right brain damaged patients with visual neglect.
RESULTS: Healthy subjects showed a leftward bias of the egocentric perspective for both visual-perceptive and visual-exploratory tasks specifically for items presented in the left hemifield. cTBS to the right TPJ, and less systematically to the right pMFG reduced this bias for visuo-spatial and exploratory visuo-motor behaviour. Further, a consecutive cTBS to the left TPJ changed the bias again towards the left for a visual-perceptive task.
CONCLUSIONS: The evidence supports the notion of an involvement of the right TPJ (and pMFG) in spatial visual attention. The observations further indicate that inhibitory non-invasive brain stimulation (cTBS) to the left TPJ has a potential for reversing a rightward bias of spatial attention when the right TPJ is dysfunctional. Accordingly, the findings could have implications for therapeutic rTMS development for right brain damaged patients with visual neglect.
摘要：
目的：该研究试图通过神经导航抑制性rTMS方案（cTBS-600）改变年轻健康受试者的视觉空间注意力，以改变被认为与视觉注意过程有关的右脑区域，即颞顶交界处(TPJ)和后中额回(pMFG)，并测试通过额外的连续cTBS对同源左大脑皮层区域的影响的可逆性。
结果：健康受试者在视觉感知和视觉探索任务中都表现出自我中心视角的向左偏向，特别是针对左半场呈现的项目。cTBS向右TPJ，较少系统地向右pMFG减少了视觉空间和探索性视觉运动行为的这种偏见。Further,对于视觉感知任务，左侧TPJ的连续cTBS再次改变了向左的偏差。
结论：证据支持右侧TPJ（和pMFG）参与空间视觉注意的概念。观察结果进一步表明，当右TPJ功能失调时，对左TPJ的抑制性非侵入性脑刺激（cTBS）具有逆转空间注意力向右偏向的潜力。因此，该研究结果可能对右脑受损的视觉忽视患者的治疗性rTMS发展有意义.
结果：健康受试者在视觉感知和视觉探索任务中都表现出自我中心视角的向左偏向，特别是针对左半场呈现的项目。cTBS向右TPJ，较少系统地向右pMFG减少了视觉空间和探索性视觉运动行为的这种偏见。Further,对于视觉感知任务，左侧TPJ的连续cTBS再次改变了向左的偏差。
结论：证据支持右侧TPJ（和pMFG）参与空间视觉注意的概念。观察结果进一步表明，当右TPJ功能失调时，对左TPJ的抑制性非侵入性脑刺激（cTBS）具有逆转空间注意力向右偏向的潜力。因此，该研究结果可能对右脑受损的视觉忽视患者的治疗性rTMS发展有意义.
