额叶中回(MFG)涉及注意力,工作记忆,和语言相关的处理。对MFG内连接的皮质下白质束的详细了解可以促进改善该回及其周围白质病变的导航,并解释手术后的发病率。我们旨在通过使用基于扩散光谱成像的纤维束成像技术,根据其与神经解剖结构的联系来表征MFG内的纤维束,并通过大体解剖解剖以进行定性视觉一致性来验证发现。
使用来自10名健康者的扩散成像数据完成了Tractography分析,参加人类Connectome项目的成人受试者。我们根据其与其他神经区域的纤维连通性评估了MFG作为一个整体组件。在两个半球的所有区域都完成了映射,得到的道体积用于计算侧向化指数。在10次尸体解剖中使用了改良的Klingler技术,以演示主要区域的位置和方向。
确定了MFG的两个主要连接:上纵束,将MFG连接到下顶叶小叶的部分,颞叶后叶,和枕骨外侧皮质;和下额枕骨束,将MFG连接到舌回和cuneus。前后短关联,还鉴定了U形纤维。
在MFG内整合的皮质下白质通路包括上纵束和下额枕叶束。MFG涉及各种涉及注意力和记忆的任务,使其成为重要的皮质区域。在本研究中强调的纤维束解剖结构的背景下,可以阐明与MFG及其周围手术相关的术后神经系统结果。
The middle frontal gyrus (
MFG) is involved in attention, working memory, and language-related processing. A detailed understanding of the subcortical white matter tracts connected within the
MFG can facilitate improved navigation of white matter lesions in and around this gyrus and explain the postoperative morbidity after surgery. We aimed to characterize the fiber tracts within the
MFG according to their connection to neuroanatomic structures through the use of diffusion spectrum imaging-based fiber tractography and validate the findings by gross anatomic dissection for qualitative visual agreement.
Tractography analysis was completed using diffusion imaging data from 10 healthy, adult subjects enrolled in the Human Connectome Project. We assessed the
MFG as a whole component according to its fiber connectivity with other neural regions. Mapping was completed on all tracts within both hemispheres, with the resultant tract volumes used to calculate a lateralization index. A modified Klingler technique was used on 10 postmortem dissections to demonstrate the location and orientation of the major tracts.
Two major connections of the MFG were identified: the superior longitudinal fasciculus, which connects the MFG to parts of the inferior parietal lobule, posterior temporal lobe, and lateral occipital cortex; and the inferior fronto-occipital fasciculus, which connected the MFG to the lingual gyrus and cuneus. Intra- and intergyral short association, U-shaped fibers were also identified.
Subcortical white matter pathways integrated within the MFG include the superior longitudinal fasciculus and inferior fronto-occipital fasciculus. The MFG is implicated in a variety of tasks involving attention and memory, making it an important cortical region. The postoperative neurologic outcomes related to surgery in and around the
MFG could be clarified in the context of the anatomy of the fiber bundles highlighted in the present study.