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Abstract：
BACKGROUND: We used data from the Global Burden of Disease, Injuries, and Risk Factors Study 2010 to report on the burden of neuropsychiatric disorders in Spain.
METHODS: The summary measure of burden used in the study was the disability-adjusted life-year (DALY), which sums of the years of life lost due to premature mortality (YLLs) and the years lived with disability (YLDs). DALYs were adjusted for comorbidity and estimated with 95% uncertainty intervals.
RESULTS: The burden of neuropsychiatric disorders accounted for 18.4% of total all-cause DALYs generated in Spain for 2010. Within this group, the top five leading causes of DALYs were: depressive disorders, Alzheimer\'s disease, migraine, substance-use disorders, and anxiety disorder, which accounted for 70.9% of all DALYs due to neuropsychiatric disorders. Neurological disorders represented 5.03% of total all cause YLLs, whereas mental and substance-use disorders accounted for 0.8%. Mental and substance-use disorders accounted for 22.4% of total YLDs, with depression being the most disabling disorder. Neurological disorders represented 8.3% of total YLDs.
CONCLUSIONS: Neuropsychiatric disorders were one of the leading causes of disability in 2010. This finding contributes to our understanding of the burden of neuropsychiatric disorders in the Spanish population and highlights the importance of prioritising neuropsychiatric disorders in the Spanish public health system.
METHODS: The summary measure of burden used in the study was the disability-adjusted life-year (DALY), which sums of the years of life lost due to premature mortality (YLLs) and the years lived with disability (YLDs). DALYs were adjusted for comorbidity and estimated with 95% uncertainty intervals.
RESULTS: The burden of neuropsychiatric disorders accounted for 18.4% of total all-cause DALYs generated in Spain for 2010. Within this group, the top five leading causes of DALYs were: depressive disorders, Alzheimer\'s disease, migraine, substance-use disorders, and anxiety disorder, which accounted for 70.9% of all DALYs due to neuropsychiatric disorders. Neurological disorders represented 5.03% of total all cause YLLs, whereas mental and substance-use disorders accounted for 0.8%. Mental and substance-use disorders accounted for 22.4% of total YLDs, with depression being the most disabling disorder. Neurological disorders represented 8.3% of total YLDs.
CONCLUSIONS: Neuropsychiatric disorders were one of the leading causes of disability in 2010. This finding contributes to our understanding of the burden of neuropsychiatric disorders in the Spanish population and highlights the importance of prioritising neuropsychiatric disorders in the Spanish public health system.
摘要：
背景：我们使用了来自全球疾病负担的数据，受伤,2010年风险因素研究报告了西班牙的神经精神疾病负担。
方法：研究中使用的负担的汇总度量是残疾调整寿命年（DALY），其中包括因过早死亡(YLL)而失去的寿命年数和残疾生活年数(YLD)。DALYs针对合并症进行了调整，并以95%的不确定度区间进行了估计。
结果：神经精神疾病的负担占2010年西班牙全因DALYs产生总量的18.4%。在这个群体中,DALYs的五大主要原因是：抑郁症，老年痴呆症,偏头痛,物质使用障碍，和焦虑症，占所有神经精神疾病DALYS的70.9%。神经系统疾病占所有原因YLL的5.03％，而精神和物质使用障碍占0.8%。精神和物质使用障碍占总YLD的22.4％，抑郁症是最致残的疾病。神经系统疾病占总YLD的8.3％。
结论：神经精神疾病是2010年致残的主要原因之一。这一发现有助于我们了解西班牙人口中神经精神疾病的负担，并强调了在西班牙公共卫生系统中优先考虑神经精神疾病的重要性。
方法：研究中使用的负担的汇总度量是残疾调整寿命年（DALY），其中包括因过早死亡(YLL)而失去的寿命年数和残疾生活年数(YLD)。DALYs针对合并症进行了调整，并以95%的不确定度区间进行了估计。
结果：神经精神疾病的负担占2010年西班牙全因DALYs产生总量的18.4%。在这个群体中,DALYs的五大主要原因是：抑郁症，老年痴呆症,偏头痛,物质使用障碍，和焦虑症，占所有神经精神疾病DALYS的70.9%。神经系统疾病占所有原因YLL的5.03％，而精神和物质使用障碍占0.8%。精神和物质使用障碍占总YLD的22.4％，抑郁症是最致残的疾病。神经系统疾病占总YLD的8.3％。
结论：神经精神疾病是2010年致残的主要原因之一。这一发现有助于我们了解西班牙人口中神经精神疾病的负担，并强调了在西班牙公共卫生系统中优先考虑神经精神疾病的重要性。
