精神分裂症患者和健康个体在言语流畅性任务期间前额叶血流动力学反应降低与 EGR3 基因多态性的关联。
关键词: DLPFC DSM-IV-TR DTI DUP DeoxyHb Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision EGR Early growth response 3 (EGR3) GAF Global Assessment of Functioning HC Hb Imaging genetics JART Japanese version of the National Adult Reading Test NIRS Near-infrared spectroscopy (NIRS) OxyHb PANSS Positive and Negative Symptom Scale Prefrontal function SNP SZ Schizophrenia VFT Verbal fluency task (VFT) deoxygenated hemoglobin concentration diffusion tensor imaging dorsolateral prefrontal cortex duration of untreated psychosis early growth response healthy control hemoglobin near-infrared spectroscopy oxygenated hemoglobin concentration schizophrenia single nucleotide polymorphism verbal fluency task
Mesh : Adult Asians Cerebrovascular Circulation / physiology DNA / genetics Early Growth Response Protein 3 / genetics False Positive Reactions Female Functional Neuroimaging Hemodynamics / physiology Hemoglobins / analysis metabolism Humans Male Neuropsychological Tests Polymorphism, Genetic / genetics Prefrontal Cortex / blood supply Psychiatric Status Rating Scales Psychomotor Performance / physiology Schizophrenia / genetics Schizophrenic Psychology Spectroscopy, Near-Infrared Verbal Behavior / physiology
来 源: DOI:10.1016/j.neuroimage.2013.08.021