关键词: ACHBP Ach Alternative binding modes CNS Docking Homology modelling LID N-Acyl diazabicycle Nicotinic acetylcholine receptor Pdb Pharmacophore elucidation SAR SP XP acetylcholine acetylcholine-binding protein central nervous system extra precision l-dopa-induced dyskinesia nAChR nicotinic acetylcholine receptor protein databank rmsd root-mean-squared-deviation standard precision structure–activity relationship α4β2 nAChR
Mesh : Azabicyclo Compounds / chemical synthesis chemistry pharmacology Binding Sites / drug effects Dose-Response Relationship, Drug Humans Ligands Models, Molecular Molecular Structure Receptors, Nicotinic / metabolism Structure-Activity Relationship
来 源: DOI:10.1016/j.bmcl.2013.07.028