关键词: EZH2 H3K27me3 H3K79me2 H4K20me3 PRC2 complex SET-domain cancer epigenetics diffuse intrinsic pontine glioma (DIPGs) glioblastoma (GBM) histone modification tumorigenesis
Mesh : Amino Acid Sequence Child Chromatin Immunoprecipitation DNA Methylation / genetics Fluorescent Antibody Technique Gene Expression Regulation, Neoplastic / genetics Glioblastoma / genetics Histone Methyltransferases Histone-Lysine N-Methyltransferase / metabolism Histones / genetics Humans Models, Biological Molecular Sequence Data Mutation, Missense / genetics
来 源:
DOI:10.4161/cc.25625
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