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Abstract：
HtrA (High temperature requirement protease A) proteins that are primarily involved in protein quality control belong to a family of serine proteases conserved from bacteria to humans. HtrAs are oligomeric proteins that share a common trimeric pyramidal architecture where each monomer comprises a serine protease domain and one or two PDZ domains. Although the overall structural integrity is well maintained and they exhibit similar mechanism of activation, subtle conformational changes and structural plasticity especially in the flexible loop regions and domain interfaces lead to differences in their active site conformation and hence in their specificity and functions.
摘要：
主要涉及蛋白质质量控制的HtrA(高温要求蛋白酶A)蛋白质属于从细菌到人类保守的丝氨酸蛋白酶家族。HtrA是具有共同的三聚体锥体结构的寡聚蛋白,其中每个单体包含丝氨酸蛋白酶结构域和一个或两个PDZ结构域。尽管整体结构完整性得到了很好的保持，并且它们表现出相似的激活机制，微妙的构象变化和结构可塑性，尤其是在柔性环区和结构域界面中，导致其活性位点构象差异，从而导致其特异性和功能差异。
