背景:口腔癌是全球第16种最常见的恶性肿瘤,死亡率很高,五年超过50%,和高发病率。口腔肿瘤治疗的效果是广泛的,有多个层面,因此,了解这些影响并预防它们对于避免与肿瘤治疗相关的口腔病理学增加至关重要,保持病人的生活质量,并提高治疗本身的疗效。
方法:一组属于牙科领域的专家,塞维利亚大学颌面外科和肿瘤学以及塞维利亚VirgendelRocio大学医院与巴伦西亚大学合作,巴塞罗那大学,巴斯克大学,制定了本临床实践指南,用于对诊断为口腔癌的患者进行适当的临床管理。临床问题以PICO格式制定。咨询的数据库是Medline/PubMed和Embase/Elsevier。在Tripdatabase上确定了有关该主题的系统评论,Cochrane图书馆和CRD(审查和传播中心)。这些建议是根据GRADE方法编写的。
结果:定义了各种建议,源自21个PICO问题,关于预防,治疗和护理因口腔癌本身的病理学及其治疗而引起的改变。
结论:本临床实践指南的编制允许根据现有的科学证据提出建议,关于口腔癌患者和接受肿瘤治疗的牙科行动,这可能对治疗这类患者的多学科团队有用。
BACKGROUND: Oral cancer is the sixteenth most common malignant neoplasm worldwide, with a high mortality rate, greater than 50% at five years, and high morbidity. The effect of oncological treatment in the oral cavity is broad and has multiple levels, therefore knowing these effects and preventing them is essential for avoiding an increase in the oral pathology related with oncological therapy, maintaining the quality of life of the patient, and improving the efficacy of the treatment itself.
METHODS: A group of experts belonging to the fields of Dentistry, Maxillofacial Surgery and Oncology of the University of Seville and the Virgen del Rocío University Hospital of Seville in collaboration with the University of Valencia, University of Barcelona, and University of the Basque Country, developed this Clinical Practice
Guideline for the proper clinical management of patients diagnosed with oral cancer. The clinical questions were formulated in PICO format. The databases consulted were Medline/PubMed and Embase/Elsevier. The systematic reviews published on the topic were identified on Tripdatabase, Cochrane Library and CRD (Centre for Reviews and Dissemination). The recommendations were prepared based on the GRADE methodology.
RESULTS: Various recommendations were defined, derived from the 21 PICO questions, referring to prevention, treatment and care for alterations arising from the pathology of oral cancer itself and its treatment.
CONCLUSIONS: The preparation of this clinical practice
guideline allows recommendations to be generated based on the scientific evidence available, on dentistry actions in patients with oral cancer and undergoing oncological treatment, which may be of use to the multidisciplinary team treating this type of patient.