免疫介导的炎性疾病患者容易发生脂肪变性肝病(SLD),已在银屑病和化脓性汗腺炎患者中观察到。我们旨在评估系统性红斑狼疮(SLE)是否与SLD相关,并确定SLE中与SLD相关的因素。这是一项横断面研究,我们纳入了2021年6月至2022年3月期间在风湿病诊所就诊的106例连续SLE患者,我们为每种SLE选择了两个性别配对对照.所有参与者都接受了FibroScan和人体测量评估。SLD定义为受控衰减参数≥275dB/m。SLE患者SLD患病率较低(21.7%vs41.5%,p<0.001)。SLE和SLD患者使用羟氯喹的频率较低(65%vs84%,p=0.04),和更高的C3水平[123mg/dl(IQR102-136)对99mg/dl(IQR78-121),p=0.004]。SLE患者SLD的相关因素包括体重指数(BMI)、腰围,葡萄糖,和C3;羟氯喹的使用是一个保护因素。在单变量分析中,SLE与SLD风险降低相关(OR0.39,95CI0.23-0.67);然而,在调整了年龄之后,BMI,腰部,葡萄糖,甘油三酯,高密度胆固醇,低密度胆固醇,白细胞,和羟氯喹,它不再相关(OR0.43,95CI0.10-1.91).总之,SLE患者的SLD患病率不高于一般人群,SLE与SLD无关。与SLD相关的因素是人体测量数据,葡萄糖,羟氯喹,C3水平。
Patients with immune-mediated inflammatory diseases are prone to steatotic liver disease (SLD), which has been observed in patients with psoriasis and hidradenitis suppurativa. We aimed to assess whether systemic lupus erythematosus (SLE) was associated with SLD and to define factors associated with SLD in SLE. This was a cross-sectional
study, we included 106 consecutive patients with SLE who were seen in the rheumatology clinic between June 2021 and March 2022 and we chose two sex-paired controls for each SLE. All the participants underwent FibroScan and anthropometric assessments. SLD was defined as a controlled attenuation parameter ≥ 275dB/m. Prevalence of SLD was lower in patients with SLE (21.7% vs 41.5%, p < 0.001). Patients with SLE and SLD had a lower frequency of hydroxychloroquine use (65% vs 84%, p = 0.04), and higher C3 levels [123mg/dl (IQR 102-136) vs 99mg/dl (IQR 78-121), p = 0.004]. Factors associated with SLD in SLE were body mass index (BMI), waist circumference, glucose, and C3; hydroxychloroquine use was a protective factor. On univariate analysis, SLE was associated with a reduced risk of SLD (OR 0.39, 95%CI 0.23-0.67); however, after adjusting for age, BMI, waist, glucose, triglycerides, high-density cholesterol, low-density cholesterol, leukocytes, and hydroxychloroquine, it was no longer associated (OR 0.43, 95%CI 0.10-1.91). In conclusion, the prevalence of SLD in patients with SLE was not higher than that in the general population, and SLE was not associated with SLD. The factors associated with SLD were anthropometric data, glucose, hydroxychloroquine, and C3 levels.