背景:研究推进乳腺癌的有效治疗对于根除乳腺癌至关重要,减少复发,提高生存率。保留乳头的乳房切除术(NSM),一种治疗乳腺癌的常用方法,经常导致并发症需要再次手术。尽管取得了进步,使用高压氧治疗(HBOT)治疗这些并发症的研究仍未得到足够的重视.因此,我们分析了HBOT在NSM患者术后护理中的疗效.方法:使用PubMed进行系统搜索,Scopus,还有Cochrane图书馆.使用PICO(人口,干预,比较,结果)框架并根据美国整形外科医师协会(ASPS)的证据水平进行分类。七项研究,总共有63名女性患者,符合纳入标准。在这些研究中,4人被归类为三级(57.1%),一个为IV级(14.3%),两个为V级(28.6%)。这些研究集中在HBOT在伤口愈合中的作用,乳房重建的成功抢救,以及HBOT的最佳时机。结果:这篇综述显示,HBOT确实具有改善组织氧合的潜力,血管化,and,因此,伤口愈合。值得注意的是,HBOT对于缓解NMS后并发症是有效的,包括感染,重新操作,皮瓣损失,血清肿,还有血肿.结论:总体而言,由于HBOT在减轻乳房切除术后发生的常见不良反应中的作用,因此在接受NSM的患者的标准术后护理方案中可能是有益的。尽管有希望的结果,最近的文献缺乏严格的临床试验和明确的对照组,强调需要进一步研究以建立标准化的HBOT协议。
Background: Research advancing effective treatments for
breast cancer is crucial for eradicating the disease, reducing recurrence, and improving survival rates. Nipple-sparing
mastectomy (NSM), a common method for treating
breast cancer, often leads to complications requiring re-operation. Despite advancements, the use of hyperbaric oxygen therapy (HBOT) for treating these complications remains underexplored. Therefore, we analyze the efficacy of HBOT in the post-operative care of patients undergoing NSM. Methods: A systematic search was conducted using PubMed, Scopus, and the Cochrane Library. Studies were assessed for eligibility using the PICO (Population, Intervention, Comparison, Outcome) framework and classified based on American Society of Plastic Surgeons (ASPS) levels of evidence. Seven studies, totaling a pool of 63 female patients, met the inclusion criteria. Among these studies, four were categorized as Level III (57.1%), one as Level IV (14.3%), and two as Level V (28.6%). These studies focused on HBOT\'s role in wound healing, the successful salvage of
breast reconstruction, and the optimal timing for HBOT. Results: This
review revealed that HBOT indeed has potential for improving tissue oxygenation, vascularization, and, consequently, wound healing. It is noted that HBOT is efficacious for mitigating post-NMS complications, including infections, re-operation, flap loss, seroma, and hematoma. Conclusions: Overall, HBOT could be beneficial in standard post-surgical care protocols for patients undergoing NSM due to its role in mitigating common adverse effects that occur after
mastectomy. Despite promising outcomes, the recent literature lacks rigorous clinical trials and well-defined control groups, underscoring the need for further research to establish standardized HBOT protocols.