背景:牙周炎是一种严重影响口腔健康的常见病。共病条件,比如糖尿病,可以提高牙周病的严重程度和整体口腔健康。因此,为了改善口腔健康和管理合并症,全面的牙周护理至关重要。这种方法可能涉及在常规口腔护理中使用含有抗微生物成分的牙膏。本文介绍了体外研究的结果,分析了含有柠檬酸锌的测试制剂的抗菌性能,明矾,氟化钠,和木糖醇牙膏(Stolin-R)。这些成分共同作用以通过控制主要负责牙周病的细菌的生长来帮助提供全面的口腔护理,从而保持最佳的口腔卫生。
目的:为了确定柠檬酸锌的抗菌性能,明矾,氟化钠,通过体外分析,以木糖醇为基础的牙膏配方可对抗关键的牙周病原体。
方法:通过最小抑制浓度(MIC)评估测试制剂的抗菌功效,最小杀菌浓度(MBC),以及对关键牙周病原体的时间依赖性抗菌评估,包括牙龈卟啉单胞菌,连翘坦菌,具核梭杆菌,中间介体普雷沃特拉,变形链球菌,和脆弱拟杆菌。
结果:试验制剂对脆弱拟杆菌具有有效的抗菌效果,具核梭杆菌,牙龈卟啉单胞菌,中间介体普雷沃特拉,变形链球菌,还有连翘坦纳菌,表现出低MIC和MBC。此外,显著减少细菌,超过99.99%,在五分钟内被观察到,强调其作为对抗牙周感染的有效辅助手段的潜力。
结论:柠檬酸锌,明矾,氟化钠,和木糖醇为基础的牙膏配方显示出对关键牙周病原体的显着抗菌活性,表明其作为维持口腔健康和抵抗牙龈感染的有效药物的潜力。
BACKGROUND: Periodontitis is a prevalent condition significantly affecting oral health. Comorbid conditions, such as diabetes, can heighten the severity of periodontal disease and overall oral health. Therefore, to enhance oral health and manage comorbid conditions, comprehensive periodontal care is essential. This approach could involve using toothpaste containing antimicrobial ingredients in routine oral care. This paper presents the results of an in vitro study analysing the antimicrobial properties of the test formulation containing zinc citrate, alum, sodium fluoride, and
xylitol-based toothpaste (Stolin-R). These ingredients work together to help in providing comprehensive oral care by controlling growth of bacteria majorly responsible for periodontal disease and thus maintaining optimal oral hygiene.
OBJECTIVE: To determine the antimicrobial properties of zinc citrate, alum, sodium fluoride, and
xylitol-based toothpaste formulation against key periodontal pathogens through in vitro analyses.
METHODS: The antimicrobial efficacy of test formulation is evaluated through minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and time-dependent antibacterial assessment against key periodontal pathogens, including Porphyromonas gingivalis, Tannerella forsythia, Fusobacterium nucleatum, Prevotella intermedia, Streptococcus mutans, and Bacteroides fragilis.
RESULTS: The test formulation demonstrated potent antimicrobial effectiveness against Bacteroides fragilis, Fusobacterium nucleatum, Porphyromonas gingivalis, Prevotella intermedia, Streptococcus mutans, and Tannerella forsythia, by exhibiting low MIC and MBC. Additionally, significant bacterial reduction, exceeding 99.99%, was observed within five minutes, emphasising its potential as an effective adjunct in combating periodontal infection.
CONCLUSIONS: Zinc citrate, alum, sodium fluoride, and
xylitol-based toothpaste formulation demonstrates significant antimicrobial activity against key periodontal pathogens, suggesting its potential as an effective agent for maintaining oral health and combating gingival infection.