PDF(Pubmed)
Abstract：
Xylitol is considered a naturally occurring antibacterial agent. It is generally believed to enhance the body\'s own innate bactericidal mechanisms. It also provides anti-adhesive effects against both Streptococcus pneumoniae and Haemophilus influenza. This study was performed to evaluate the efficacy and safety of xylitol nasal irrigation in the postoperative care of functional endoscopic sinus surgery (FESS). Patients with chronic rhinosinusitis who received FESS were recruited and randomly assigned to two groups at one month post-surgery. Thirty-five patients in the xylitol group received 400 mL of 5% xylitol nasal irrigation daily for 2 months, while another 35 in the normal saline (NS) group received 400 mL of NS nasal irrigation daily for 2 months. Prior to FESS, as well as before and after nasal irrigation, sinonasal symptoms were assessed through the 22-item Sino-Nasal Outcome Test Questionnaire. The patients also underwent an endoscopic examination while undergoing nasal function tests, and a cytokine measurement of the nasal lavage and a bacterial culture from the middle meatus were performed. The safety of the nasal irrigation was assessed through any self-reported adverse events, the Eustachian Tube Dysfunction Patient Questionnaire and the eustachian tube function test. The endoscopic scores and olfactory threshold significantly decreased after xylitol irrigation when compared with those before irrigation. The prevalence of Staphylococcus aureus in the nasal secretions also decreased significantly after xylitol irrigation. The amounts of Interleukin-5 and Interleukin-17A were significantly increased in the nasal lavage after xylitol irrigation. No side effects, including those related to eustachian tube function, were seen after nasal irrigation in both groups. Our results showed that xylitol nasal irrigation was both beneficial and safe during the postoperative care of FESS.
摘要：
木糖醇被认为是天然存在的抗菌剂。一般认为它能增强机体自身的先天杀菌机制。它还提供抗肺炎链球菌和流感嗜血杆菌的抗粘附作用。本研究旨在评估木糖醇鼻腔冲洗在功能性内窥镜鼻窦手术（FESS）术后护理中的有效性和安全性。招募接受FESS的慢性鼻-鼻窦炎患者，并在术后1个月随机分为两组。木糖醇组35例患者每天接受400毫升5%木糖醇鼻腔冲洗，持续2个月，而另外35名生理盐水（NS）组每天接受400mLNS鼻腔冲洗，持续2个月。在FESS之前，以及鼻腔冲洗之前和之后，鼻窦症状通过22项鼻窦结果测试问卷进行评估。患者在接受鼻功能检查的同时还接受了内窥镜检查，并进行了鼻腔灌洗的细胞因子测量和中鼻道的细菌培养。通过任何自我报告的不良事件评估鼻腔冲洗的安全性。咽鼓管功能障碍患者问卷和咽鼓管功能测试。与冲洗前相比，木糖醇冲洗后的内窥镜评分和嗅觉阈值显着降低。木糖醇冲洗后，鼻腔分泌物中金黄色葡萄球菌的患病率也显着降低。木糖醇冲洗后，鼻腔灌洗中白细胞介素5和白细胞介素17A的含量显着增加。没有副作用,包括与咽鼓管功能有关的，两组均在鼻腔冲洗后见。我们的结果表明，木糖醇鼻腔冲洗在FESS的术后护理中既有益又安全。
