■丙泊酚是临床上广泛使用的静脉麻醉药。然而,容易引起老年患者严重的循环波动,所以剂量应该适当减少。研究表明,腕踝针(WAA)可以减少无痛内窥镜检查患者的丙泊酚用量。不幸的是,目前尚无关于WAA用于老年患者麻醉时是否会减少丙泊酚用量的报道。目的观察WAA对老年患者丙泊酚用量的影响,为老年患者全身麻醉下维持循环稳定提供一种新的方法。
■2022年10月至2022年12月,选择河北省中医院。将44例泌尿外科全身麻醉老年患者按照完全随机方法随机分为两组,WAA组,由22个人组成,和非WAA(NWAA)组,由22个人组成。两组均于麻醉前在同一部位进行WAA或假针针刺,分别,针一直保存到手术结束。在操作过程中,根据麻醉监测仪的视野深度监测密度频谱阵列(DSA)和麻醉意识指数(Ai)调整丙泊酚的剂量。
■共有44名患者参加了这项研究,他们都完成了实验。性别无显著差异,年龄,高度,体重,麻醉持续时间,肝肾功能,油炸脆弱量表得分,日常生活活动(ADL),两组年龄校正后的Charlson合并症指数(aCCI)和迷你认知测验(Mini-Cog)(P>0.05),但异丙酚总剂量(WAA=121.5,NWAA=170.5)mg和维持剂量(WAA=1.02±0.55,NWAA=1.76±0.67)mg/kg/h,术中血管活性药物的利用率,麻醉后苏醒时间(WAA=2,NWAA=3)min和外科医生满意度(WAA=9,NWAA=8.5)差异有统计学意义(P<0.05)。
■与NWAA组相比,WAA组能减少丙泊酚在有外分泌的老年患者麻醉中的用量,有利于循环的稳定。
■中国临床试验注册中心(ID:ChiCTR2100054132)。
UNASSIGNED: Propofol is a widely used intravenous anesthetic in clinic. However, it is easy to cause serious circulatory fluctuation in elderly patients, so the dose should be reduced as appropriate. Studies have shown that wrist-ankle acupuncture (WAA) can reduce the dosage of propofol in patients undergoing painless endoscopy. Unfortunately, there is no report on whether WAA will reduce the dosage of propofol when used for anesthesia in elderly patients. The purpose of this study is to observe the effect of WAA on propofol dosage in elderly patients, and to provide a new method for maintaining circulatory stability in elderly patients under general anesthesia.
UNASSIGNED: From October 2022 to December 2022, Hebei Provincial Hospital of Traditional Chinese Medicine was selected. Forty-four elderly patients undergoing general anesthesia in urology department were randomly divided into two groups according to the complete random method with WAA group, consisting of 22 individuals, and non-WAA (NWAA) group, also consisting of 22 individuals. Both groups were treated with WAA or false needle acupuncture at the same site before anesthesia, respectively, and the needle was kept until the operation was finished. During the operation, the dosage of propofol was adjusted according to the depth of field monitoring density spectrum array (DSA) and anesthesia consciousness index (Ai) with anesthesia monitor.
UNASSIGNED: A total of 44 patients participated in this study, and all of them completed the experiment. There were no significant difference in sex, age, height, weight, duration of anesthesia, liver and kidney function, score of Fried frailty scale, activity of daily living (ADL), age-adjusted Charlson comorbidity index (aCCI) and mini-cognitive test (Mini-Cog) between the two groups (P>0.05), but the total dose of propofol (WAA =121.5, NWAA =170.5) mg and maintenance dose (WAA =1.02±0.55, NWAA =1.76±0.67) mg/kg/h, utilization rate of vasoactive drugs during operation, recovery time after anesthesia (WAA =2, NWAA =3) min and surgeon satisfaction (WAA =9, NWAA =8.5) had significant differences (P<0.05).
UNASSIGNED: Compared with NWAA group, WAA group could reduce the dosage of propofol in anesthesia for elderly patients with exocrine secretion and was beneficial to circulatory stability.
UNASSIGNED: Chinese Clinical Trial Registry (ID: ChiCTR2100054132).