我们检查了核梭杆菌(F.无癌患者（n=67；N组）的非肿瘤性Barrett食管（BE）中的核子）和完整的梭杆菌（泛梭菌），食管腺癌（EAC）（n=27）和EAC组织（n=22）。F.核仁仅在22.7%的EAC组织中检测到。泛梭菌在EAC组织中富集，并与侵袭性临床病理特征相关。非肿瘤性BE中泛梭菌的数量与疝和端粒缩短的存在有关。结果表明Fusobacterium物种在EAC和BE中的潜在关联，具有临床病理和分子特征。
We examined Fusobacterium nucreatum (F. nucleatum) and whole Fusobacterium species (Pan-fusobacterium) in non-neoplastic Barrett\'s esophagus (BE) from patients without cancer (n = 67; N group), with esophageal adenocarcinoma (EAC) (n = 27) and EAC tissue (n = 22). F. nucleatum was only detectable in 22.7% of EAC tissue. Pan-fusobacterium was enriched in EAC tissue and associated with aggressive clinicopathological features. Amount of Pan-fusobacterium in non-neoplastic BE was correlated with presence of hital hernia and telomere shortening. The result suggested potential association of Fusobacterium species in EAC and BE, featuring clinicpathological and molecular features.
