Abstract：
We examined Fusobacterium nucreatum (F. nucleatum) and whole Fusobacterium species (Pan-fusobacterium) in non-neoplastic Barrett\'s esophagus (BE) from patients without cancer (n = 67; N group), with esophageal adenocarcinoma (EAC) (n = 27) and EAC tissue (n = 22). F. nucleatum was only detectable in 22.7% of EAC tissue. Pan-fusobacterium was enriched in EAC tissue and associated with aggressive clinicopathological features. Amount of Pan-fusobacterium in non-neoplastic BE was correlated with presence of hital hernia and telomere shortening. The result suggested potential association of Fusobacterium species in EAC and BE, featuring clinicpathological and molecular features.
摘要：
我们检查了核梭杆菌(F.无癌患者（n=67；N组）的非肿瘤性Barrett食管（BE）中的核子）和完整的梭杆菌（泛梭菌），食管腺癌（EAC）（n=27）和EAC组织（n=22）。F.核仁仅在22.7%的EAC组织中检测到。泛梭菌在EAC组织中富集，并与侵袭性临床病理特征相关。非肿瘤性BE中泛梭菌的数量与疝和端粒缩短的存在有关。结果表明Fusobacterium物种在EAC和BE中的潜在关联，具有临床病理和分子特征。
