水通道蛋白(AQP)是普遍存在的通道蛋白,通过允许水的运输,在细胞环境的稳态中起关键作用。化学品,和离子。它们可以在许多不同类型的细胞和器官中找到,包括肺,眼睛,大脑,腺体,和血管。通过控制细胞生长等过程中的渗透水通量,能量代谢,迁移,附着力,和扩散,AQP能够在广泛的细胞过程中发挥其调节作用。不同来源的肿瘤细胞显着表达AQP,特别是在具有高转移倾向的恶性肿瘤中。对AQPs在细胞迁移和增殖中的作用的新见解加强了AQPs在肿瘤生物学中至关重要的观点。AQP最近被证明是对抗致病性抗体和转移性细胞迁移的强大工具,尽管水通道蛋白在病理学中的分子过程尚未完全建立。在这次审查中,我们将讨论AQP在身体中表达的几种方式,它们在肿瘤发生中扮演的独特角色,以及可用于治疗癌症的新型治疗方法。
Aquaporins (AQPs) are ubiquitous channel proteins that play a critical role in the homeostasis of the cellular environment by allowing the transit of water, chemicals, and ions. They can be found in many different types of cells and organs, including the lungs, eyes, brain, glands, and blood vessels. By controlling the osmotic water flux in processes like cell growth, energy metabolism, migration, adhesion, and proliferation, AQPs are capable of exerting their regulatory influence over a wide range of cellular processes. Tumour cells of varying sources express AQPs significantly, especially in malignant tumours with a high propensity for metastasis. New insights into the roles of AQPs in cell migration and proliferation reinforce the notion that AQPs are crucial players in tumour biology. AQPs have recently been shown to be a powerful tool in the fight against pathogenic antibodies and metastatic cell migration, despite the fact that the molecular processes of aquaporins in pathology are not entirely established. In this review, we shall discuss the several ways in which AQPs are expressed in the body, the unique roles they play in tumorigenesis, and the novel therapeutic approaches that could be adopted to treat carcinoma.