PDF(Pubmed)
Abstract：
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is increasingly recognized as a significant health issue. Emerging research has focused on the role of the gut microbiota in NAFLD, emphasizing the gut-liver axis. This study aimed to identify key research trends and guide future investigations in this evolving area.
METHODS: This bibliometric study utilized Scopus to analyze global research on the link between the gut microbiota and NAFLD. The method involved a search strategy focusing on relevant keywords in article titles, refined by including only peer-reviewed journal articles. The data analysis included bibliometric indicators such as publication counts and trends, which were visualized using VOSviewer software version 1.6.20 for network and co-occurrence analysis, highlighting key research clusters and emerging topics.
RESULTS: Among the 479 publications on the gut microbiota and NAFLD, the majority were original articles (n = 338; 70.56%), followed by reviews (n = 119; 24.84%). The annual publication count increased from 1 in 2010 to 118 in 2022, with a significant growth phase starting in 2017 (R2 = 0.9025, p < 0.001). The research was globally distributed and dominated by China (n = 231; 48.23%) and the United States (n = 90; 18.79%). The University of California, San Diego, led institutional contributions (n = 18; 3.76%). Funding was prominent, with 62.8% of the articles supported, especially by the National Natural Science Foundation of China (n = 118; 24.63%). The average citation count was 43.23, with an h-index of 70 and a citation range of 0 to 1058 per article. Research hotspots shifted their focus post-2020 toward the impact of high-fat diets on NAFLD incidence.
CONCLUSIONS: This study has effectively mapped the growing body of research on the gut microbiota-NAFLD relationship, revealing a significant increase in publications since 2017. There is significant interest in gut microbiota and NAFLD research, mainly led by China and the United States, with diverse areas of focus. Recently, the field has moved toward exploring the interconnections among diet, lifestyle, and the gut-liver axis. We hypothesize that with advanced technologies, new opportunities for personalized medicine and a holistic understanding of NAFLD will emerge.
METHODS: This bibliometric study utilized Scopus to analyze global research on the link between the gut microbiota and NAFLD. The method involved a search strategy focusing on relevant keywords in article titles, refined by including only peer-reviewed journal articles. The data analysis included bibliometric indicators such as publication counts and trends, which were visualized using VOSviewer software version 1.6.20 for network and co-occurrence analysis, highlighting key research clusters and emerging topics.
RESULTS: Among the 479 publications on the gut microbiota and NAFLD, the majority were original articles (n = 338; 70.56%), followed by reviews (n = 119; 24.84%). The annual publication count increased from 1 in 2010 to 118 in 2022, with a significant growth phase starting in 2017 (R2 = 0.9025, p < 0.001). The research was globally distributed and dominated by China (n = 231; 48.23%) and the United States (n = 90; 18.79%). The University of California, San Diego, led institutional contributions (n = 18; 3.76%). Funding was prominent, with 62.8% of the articles supported, especially by the National Natural Science Foundation of China (n = 118; 24.63%). The average citation count was 43.23, with an h-index of 70 and a citation range of 0 to 1058 per article. Research hotspots shifted their focus post-2020 toward the impact of high-fat diets on NAFLD incidence.
CONCLUSIONS: This study has effectively mapped the growing body of research on the gut microbiota-NAFLD relationship, revealing a significant increase in publications since 2017. There is significant interest in gut microbiota and NAFLD research, mainly led by China and the United States, with diverse areas of focus. Recently, the field has moved toward exploring the interconnections among diet, lifestyle, and the gut-liver axis. We hypothesize that with advanced technologies, new opportunities for personalized medicine and a holistic understanding of NAFLD will emerge.
摘要：
背景：非酒精性脂肪性肝病（NAFLD）越来越被认为是一个重要的健康问题。新兴的研究集中在肠道微生物群在NAFLD中的作用，强调肠-肝轴。这项研究旨在确定关键的研究趋势，并指导未来在这一不断发展的领域的研究。
方法：本文献计量研究利用Scopus分析了有关肠道菌群与NAFLD之间联系的全球研究。该方法涉及一种专注于文章标题中相关关键词的搜索策略，通过只包括同行评审的期刊文章来完善。数据分析包括文献计量指标，如出版物数量和趋势，使用VOSviewer软件版本1.6.20进行网络和共现分析，突出关键研究集群和新兴主题。
结果：在关于肠道菌群和NAFLD的479篇出版物中，大多数是原创文章(n=338；70.56%)，其次是评论（n=119；24.84%）。年度出版物数量从2010年的1个增加到2022年的118个，从2017年开始进入显著的增长阶段（R2=0.9025，p<0.001）。该研究在全球范围内分布，并以中国（n=231；48.23％）和美国（n=90；18.79％）为主。加州大学,圣地亚哥,主导机构捐款（n=18；3.76%）。资金是突出的，62.8%的文章得到支持，特别是国家自然科学基金(n=118；24.63%)。平均引文计数为43.23，h指数为70，每篇文章的引文范围为0至1058。研究热点在2020年后将重点转向高脂肪饮食对NAFLD发病率的影响。
结论：这项研究有效地绘制了有关肠道微生物群与NAFLD关系的研究，自2017年以来，出版物大幅增加。对肠道微生物群和NAFLD研究有很大的兴趣，主要由中国和美国领导，具有不同的重点领域。最近,该领域已经开始探索饮食之间的相互联系，生活方式,和肠-肝轴。我们假设有了先进的技术，个性化医疗的新机会和对NAFLD的全面理解将会出现。
方法：本文献计量研究利用Scopus分析了有关肠道菌群与NAFLD之间联系的全球研究。该方法涉及一种专注于文章标题中相关关键词的搜索策略，通过只包括同行评审的期刊文章来完善。数据分析包括文献计量指标，如出版物数量和趋势，使用VOSviewer软件版本1.6.20进行网络和共现分析，突出关键研究集群和新兴主题。
结果：在关于肠道菌群和NAFLD的479篇出版物中，大多数是原创文章(n=338；70.56%)，其次是评论（n=119；24.84%）。年度出版物数量从2010年的1个增加到2022年的118个，从2017年开始进入显著的增长阶段（R2=0.9025，p<0.001）。该研究在全球范围内分布，并以中国（n=231；48.23％）和美国（n=90；18.79％）为主。加州大学,圣地亚哥,主导机构捐款（n=18；3.76%）。资金是突出的，62.8%的文章得到支持，特别是国家自然科学基金(n=118；24.63%)。平均引文计数为43.23，h指数为70，每篇文章的引文范围为0至1058。研究热点在2020年后将重点转向高脂肪饮食对NAFLD发病率的影响。
结论：这项研究有效地绘制了有关肠道微生物群与NAFLD关系的研究，自2017年以来，出版物大幅增加。对肠道微生物群和NAFLD研究有很大的兴趣，主要由中国和美国领导，具有不同的重点领域。最近,该领域已经开始探索饮食之间的相互联系，生活方式,和肠-肝轴。我们假设有了先进的技术，个性化医疗的新机会和对NAFLD的全面理解将会出现。
