目的:为了确定黄斑厚度(MT)与视野(VF)参数之间的关系,以及青光眼和高眼压(OH)患者视网膜神经纤维层(RNFL)厚度的变化。
方法:光谱域光学相干断层扫描(SD-OCT)的横截面统计分析与几个VF参数(平均缺陷-MD和损失方差-LV)的比较,来自青光眼或OH患者的70只眼的非随机样本。使用社会科学统计软件包进行统计分析。所使用的相关系数通过Spearman相关性确定,并且p<0.05的值被认为是统计学上显著的。
结果:VF参数与MT降低之间存在显着相关性(MD:r=-0.363,p=0.002;LV:r=-0.378,p=0.001)。当我们比较平均MT为270至300μm的组的LV时,结果更为显着(r=-0.413,p=0.015)。在MT<270μm的组中,上黄斑和下黄斑之间的不对称与LV相关(r=0.432,p=0.019)。上颞和下颞RNFL的变薄与上MT和下MT的减少之间也存在显着相关性(p<0.001)。
结论:青光眼患者黄斑视网膜厚度的谱域光学相干断层扫描测量与VF参数和RNFL参数相关。这种关系首先用章鱼101®制成的静态计算机视野检查来证明。这些结果可以为评估和监测青光眼患者提供有价值的帮助,建立结构和功能之间的相关性。黄斑中视网膜厚度的测量可能是早期检测结构变化及其与功能缺陷的相关性的另一种工具。
■MotaM,VazFT,RamalhoM,PedrosaC,LisboaM,KakuP,青光眼患者黄斑厚度评估及其与视野的相关性。JCurr青光眼Pract2016;10(3):85-90。
OBJECTIVE: To determine the relationship between macular thickness (MT) and visual field (VF) parameters, as well as with changes in the retinal nerve fiber layer (RNFL) thickness in patients with glaucoma and ocular hypertension (OH).
METHODS: Cross-sectional statistical analysis of spectral domain optical coherence tomography (SD-OCT) compared with several VF parameters (mean defect - MD and loss variance - LV), in a nonrandom sample of 70 eyes from patients with glaucoma or OH. Statistical analysis was performed using Statistical Package for Social Sciences®. The correlation coefficient used was determined by Spearman correlation and the value of p < 0.05 was considered statistically significant.
RESULTS: A significant correlation was seen between VF parameters and decrease in MT (MD: r = -0.363, p = 0.002; LV: r=-0.378, p = 0.001). The results were more significant when we compared the LV in the group with average MT 270 to 300 μm (r = -0.413, p = 0.015). Asymmetry between the superior macula and inferior macula correlated with LV (r = 0.432, p = 0.019) in the group with MT < 270 μm. There was also a significant correlation between thinning of superior-temporal and inferior-temporal RNFL and the decrease of the superior and inferior MT respectively (p < 0.001).
CONCLUSIONS: Spectral domain optical coherence tomography measurements of retinal thickness in the macula correlate with VF parameters and RNFL parameters in glaucoma patients. This relationship was first demonstrated with static computerized perimetry made with Octopus 101®. These results can be a valuable aid for evaluating and monitoring of glaucoma patients, establishing a correlation between structure and function. Measurements of retinal thickness in the macula may be an additional instrument for early detection of structural changes and its correlation with functional defects.
UNASSIGNED: Mota M, Vaz FT, Ramalho M, Pedrosa C, Lisboa M, Kaku P, Esperancinha F. Macular Thickness Assessment in Patients with Glaucoma and Its Correlation with Visual Fields. J Curr Glaucoma Pract 2016;10(3):85-90.