This manuscript introduces an innovative multi-stage image fusion framework that adeptly integrates infrared (IR) and visible (VIS) spectrum images to surmount the difficulties posed by low-light settings. The approach commences with an initial preprocessing stage, utilizing an Efficient Guided Image Filter for the infrared (IR) images to amplify edge boundaries and a function for the visible (VIS) images to boost local contrast and brightness. Utilizing a two-scale decomposition technique that incorporates Lipschitz constraints-based smoothing, the images are effectively divided into distinct base and detail layers, thereby guaranteeing the preservation of essential structural information. The process of fusion is carried out in two distinct stages: firstly, a method grounded in Bayesian theory is employed to effectively combine the base layers, so effectively addressing any inherent uncertainty. Secondly, a Surface from Shade (SfS) method is utilized to ensure the preservation of the scene\'s geometry by enforcing integrability on the detail layers. Ultimately a Choose Max principle is employed to determine the most prominent textural characteristics, resulting in the amalgamation of the base and detail layers to generate an image that exhibits a substantial enhancement in both clarity and detail. The efficacy of our strategy is substantiated by rigorous testing, showcasing notable progressions in edge preservation, detail enhancement, and noise reduction. Consequently, our method presents significant advantages for real-world applications in image analysis.

Green energy technology is generally becoming one of hot issues that need to be solved due to the adverse effects on the environment of fossil fuels. One of the strategies being studied and developed by theorists and experimentalists is the use of photoelectrochemical (PEC) cells, which are emerging as a candidate to produce hydrogen from water splitting. However, creating photoelectrodes that meet the requirements for PEC water splitting has emerged as the primary obstacle in bringing this technology to commercial fruition. Here, we construct a heterostructure, which consists of MoS2/TiO2/Au nanoparticles (NPs) to overcome the drawbacks of the photoanode. Owing to the dependence on charge transfer, the bandgap of MoS2/TiO2and the utilization the Au NPs as a stimulant for charges separation of TiO2by localized surface plasmon resonances effect as well as the increase of hot electron injection to cathode, leading to photocatalytic activities are improved. The results have recorded a significant increase in the photocurrent density from 2.3μAcm-2of TiO2to approximately 16.3μAcm-2of MoS2/TiO2/Au NPs. This work unveils a promising route to enhance the visible light adsorption and charge transfer in photo-electrode of the PEC cells by combining two-dimensional materials with metal NPs.

The limited access to fresh water and the increased presence of emergent pollutants (EPs) in wastewater has increased the interest in developing strategies for wastewater remediation, including photocatalysis. Graphitic carbon nitride (g-C3N4) is a 2D non-metal material with outstanding properties, such as a 2.7 eV bandgap and physicochemical stability, making it a promising photocatalyst. This work reports the process of obtaining high-surface-area (SA) g-C3N4 using the thermal-exfoliation process and the posterior effect of Ag-nanoparticle loading over the exfoliated g-C3N4 surface. The photocatalytic activity of samples was evaluated through methylene blue (MB) degradation under visible-light radiation and correlated to its physical properties obtained by XRD, TEM, BET, and UV-Vis analyses. Moreover, 74% MB degradation was achieved by exfoliated g-C3N4 compared to its bulk counterpart (55%) in 180 min. Moreover, better photocatalytic performances (94% MB remotion) were registered at low Ag loading, with 5 wt.% as the optimal value. Such an improvement is attributed to the synergetic effect produced by a higher SA and the role of Ag nanoparticles in preventing charge-recombination processes. Based on the results, this work provides a simple and efficient methodology to obtain Ag/g-C3N4 photocatalysts with enhanced photocatalytic performance that is adequate for water remediation under sunlight conditions.

UNASSIGNED: Despite advancements in treatments of multiple sclerosis (MS), there is a lack of awareness of early MS symptoms, especially in students and the public, contributing to delays in diagnosis and treatment. This review aims to identify gaps in tools to increase awareness and to provide a bilingual framework to facilitate recognition of early MS symptoms.
UNASSIGNED: We performed a literature review to determine the use of English and Spanish mnemonics in MS education for medical students and patients.
UNASSIGNED: There is no educational tool to help remember the early signs of MS at present. Here we present a framework for early awareness encompassed in the bilingual mnemonics VISIBLY (English) and VISIBLE (Spanish). VISIBLY stands for (1) Vision changes: Painful vision loss, loss of color vision or double vision; (2) Belly or Back numbness and Balance issues; (3) Limb weakness or Numbness; (4), Young people. Spanish version is included in the manuscript.
UNASSIGNED: We posit that VISIBL-MS provides a framework for MS awareness that addresses the interconnection between language, culture, health literacy, and health outcomes and can be a useful educational tool to tackle the effects of health literacy on diverse communities.

Visual detection assay based on aptamer unmodified gold nanoparticles shows great potential in biotechnology. Here, we reported a visible, salt-free and highly sensitive tetracycline (TC) assay based on a colloidally stable mixture of AuNPs that contains poly (diallyl dimethylammonium chloride) capped AuNPs ((+)AuNPs) and tetracycline-specific aptamer capped AuNPs (Apt-capped AuNPs). This reported TC assay was visible and salt-free that did not need any salt during TC detection. With naked eyes, nanomolar tetracycline concentrations could be identified within 20 min. A detection limit of tetracycline down to a concentration of 1.0 fM with a broad detection range of 8 order of magnitudes (5 × 10-14 M to 5 × 10-6 M) was reached. Furthermore, the reported TC assay also exhibited good selectivity for tetracycline over other antibiotics, metal cations, proteins and amino acids. These findings clearly demonstrated the high potential of the reported TC assay for TC detection and monitoring.

Healthcare-associated infections, often identified as hospital-acquired infections (HAIs), are typically not present during patient contact or admission. Healthcare-associated infections cause longer lengths of stay, increasing costs and mortality. HAI occurring in trauma patients increases the risk for length of stay and higher inpatient costs. Many HAIs are preventable. Antibiotic resistance has increased to a high level making proper treatment increasingly difficult due to organisms resistant to common antibiotics. Therefore, there is a need for alternate forms of attack against these pathogens. Currently, the application of light for the treatment of topical infections has been used. Ultraviolet (UV) light has well-documented antimicrobial properties. UV is damaging to DNA and causes the degradation of plastics, etc., so its use for medical purposes is limited. Using visible light may be more promising. 405-nm light sterilization has been shown to be highly efficacious in reducing bacteria. Light Line Medical, Inc.\'s (LLM) patented visible-light platform technology for infection prevention may create a global shift in the prevention of healthcare-associated infections. LLM has developed a proprietary method of delivering light to prevent catheter-associated infections. This technology uses non-UV visible light and can kill both bacteria and prevent biofilm inside and outside a luminal catheter. This is significant as prevention is key. Independent analysis of the prototype system showed the application of the device met the acceptance criterion of 4 x 109-10 reduction in Candida albicans, Staphylococcus aureus, Pseudomonas aeruginosa, and other bacteria and fungal species. Further design evolution for this technology continues, and the FDA submission process is underway.

The European Shock Tube for High-Enthalpy Research is a new state-of-the-art facility, tailored for the reproduction of spacecraft planetary entries in support of future European exploration missions, developed by an international consortium led by Instituto de Plasmas e Fusão Nuclear and funded by the European Space Agency. Deployed state-of-the-art diagnostics include vacuum-ultraviolet to ultraviolet, visible, and mid-infrared optical spectroscopy setups, and a microwave interferometry setup. This work examines the specifications and requirements for high-speed flow measurements, and discusses the design choices for the main diagnostics. The spectroscopy setup covers a spectral window between 120 and 5000 nm, and the microwave interferometer can measure electron densities up to 1.5 × 1020 electrons/m3. The main design drivers and technological choices derived from the requirements are discussed in detail herein.

Atopic dermatitis (AD) is severely burdensome, and there has been poor characterization of any differences in impact based on the area affected.
To estimate the prevalence and HRQoL impact of head/face/neck/hand (HFNH) involvement among patients with moderate-to-severe atopic dermatitis.
All TARGET-DERM AD registry patients with moderate/severe Investigator Global Assessment (vIGA-AD) were assessed using the Patient Oriented SCORing Atopic Dermatitis, Patient Oriented Eczema Measure (POEM) and the (Children\'s) Dermatology Life Quality Index ((C)DLQI).
541 participants met the criteria (75.0% adults) and 84% (N = 453) reported HFNH involvement. HFNH and non-HFNH involved participants had similar characteristics; 55.2% female and 46.9% White. Compared to the non-HFNH involved, the involved had severe vIGA-AD (28.5% vs 16.3%, P = .02) and higher median body surface area affected (15% vs 10%, P ≤ .01) and were twice as likely to have higher (C)DLQI and POEM scores.
This was an analysis of real-world and patient reported outcome data.
Real-world HFNH involved AD patients were associated with significantly worse quality of life, POEM/(C)DLQI, and more severe disease. Detailed assessments of specific areas affected by AD are needed to personalize treatment.

Cities evolve and change with economic development and population growth, and urban planning laws in Taiwan have regulations that should be comprehensively reviewed every six years. Most current government policies aim to add new disaster prevention shelters or rescue stations. An economical way to improve the disaster prevention capabilities of urban planning is through examining or reviewing spatial structures and disaster prevention plans from the perspective of citizens or residents. The UN Office of Disaster Risk Reduction (UNDRR) launched the Making Cities Resilient Campaign policy to enhance disaster-resistant and sustainable urban environments through integrated disaster mitigation, reduction, response, and evacuation plans. This study used space syntax to ascertain evacuation route features using geometric distance analysis. There was 31.61% efficiency in relation to accessible roads on a comprehensive map. We could clearly see that since the areas in the first quadrant were relatively close to accessible roads, and there was an area that was not connected to the existing evacuation channels. The increased number of channels was more accessible and extensive. Such suggestions are helpful for government departments to prepare for disaster management. The spatial characteristics of the physical environment are explained by the accessibility and efficiency of axial maps and visibility analyzed by space syntax. Our findings reveal that space syntax is an important application when examining evacuation maps.

BACKGROUND: Intranasal phototherapy offers an alternative treatment method for patients with allergic rhinitis who cannot benefit from intranasal corticosteroids and oral antihistamines. Different wavelengths have been tried with promising results.
OBJECTIVE: In this present study, we aimed to investigate the effects of visible light-infrared light phototherapy on clinical improvements together with its cytologic effects in patients with allergic rhinitis.
METHODS: Patients with confirmed allergic rhinitis were given a 4-week course of intranasal phototherapy treatment. Weekly symptom questionnaires were applied to monitor clinical effects. Nasal lavage specimens were obtained before the start and at the completion of the 4-week therapy. Fluorescence-activated cell sorting analyses of CD16+, CD24+, and CD 45+ cells were performed. Statistical analyses are performed of weekly changes in symptoms and cell counts.
RESULTS: CD45+CD16highCD24+ neutrophil count in nasal lavages decreased significantly whereas CD45+CD16dim/-CD24+ eosinophil counts significantly increased and CD45+ granulocyte counts remained unchanged. Symptom scores including nasal itching, nasal discharge, nasal obstruction, sneezing, eye itching, throat itching, and ear itching all statistically decreased compared to baseline at the end of 4 weeks.
CONCLUSIONS: Four-week course of intranasal phototherapy with visible and infrared light leads to clinical improvement in allergic rhinitis patients.