背景:鼻内光疗为不能从鼻内皮质类固醇和口服抗组胺药获益的过敏性鼻炎患者提供了一种替代治疗方法。已经尝试了不同的波长,结果有希望。
目的:在本研究中,我们的目的是研究可见光-红外光光疗对过敏性鼻炎患者的临床改善及其细胞学效应的影响。
方法:对确诊为过敏性鼻炎的患者进行为期4周的鼻内光疗治疗。每周使用症状问卷来监测临床效果。在4周治疗开始之前和结束时获得鼻腔灌洗标本。CD16+的荧光激活细胞分选分析,CD24+,和CD45+细胞进行。对症状和细胞计数的每周变化进行统计分析。
结果:鼻灌液中CD45+CD16highCD24+中性粒细胞计数显著下降,而CD45+CD16dim/-CD24+嗜酸性粒细胞计数显著增加,CD45+粒细胞计数保持不变。症状评分包括鼻痒,鼻腔分泌物,鼻塞,打喷嚏,眼睛瘙痒,喉咙瘙痒,在4周结束时,与基线相比,耳朵瘙痒在统计学上都有所下降。
结论:4周疗程的可见光和红外光鼻内光疗可导致过敏性鼻炎患者的临床改善。
BACKGROUND: Intranasal phototherapy offers an alternative treatment method for patients with allergic rhinitis who cannot benefit from intranasal corticosteroids and oral antihistamines. Different wavelengths have been tried with promising results.
OBJECTIVE: In this present study, we aimed to investigate the effects of
visible light-infrared light phototherapy on clinical improvements together with its cytologic effects in patients with allergic rhinitis.
METHODS: Patients with confirmed allergic rhinitis were given a 4-week course of intranasal phototherapy treatment. Weekly symptom questionnaires were applied to monitor clinical effects. Nasal lavage specimens were obtained before the start and at the completion of the 4-week therapy. Fluorescence-activated cell sorting analyses of CD16+, CD24+, and CD 45+ cells were performed. Statistical analyses are performed of weekly changes in symptoms and cell counts.
RESULTS: CD45+CD16highCD24+ neutrophil count in nasal lavages decreased significantly whereas CD45+CD16dim/-CD24+ eosinophil counts significantly increased and CD45+ granulocyte counts remained unchanged. Symptom scores including nasal itching, nasal discharge, nasal obstruction, sneezing, eye itching, throat itching, and ear itching all statistically decreased compared to baseline at the end of 4 weeks.
CONCLUSIONS: Four-week course of intranasal phototherapy with
visible and infrared light leads to clinical improvement in allergic rhinitis patients.