vertebral

椎体
  • 文章类型: Case Reports
    脊柱AVM的骨内发生是轶事,以前只有四例这样的病例报告。这是颈椎中脊髓骨内AVM的第一份报告。一名44岁的男性患者有2个月的进行性四肢瘫痪和膀胱功能障碍病史。磁共振成像显示C4和C5椎体内有多个流动空隙,和导致脊髓压迫的硬膜外部分。CT显示两个级别的骨广泛破坏。脊髓血管造影证实了骨内AVM的诊断。注意到AVM是由上行颈动脉和椎动脉的分支喂养的。鼻窦排入椎静脉丛,然后通过边缘窦排入颈静脉。患者接受了AVM的部分栓塞。试图进行手术切除,但发现由于大出血而不可行。进行了360度稳定和减压层切除术,在一年的随访中导致临床改善和疾病稳定。通过简要的文献综述,讨论了该案例及其管理困境。
    Intraosseous occurrence of a spinal AVM is anecdotal, with only four such cases reported previously. This is the first report of a spinal intraosseous AVM in the cervical vertebrae. A 44-year-old male patient presented with a 2-month history of progressive quadriparesis and bladder dysfunction. Magnetic resonance imaging showed multiple flow voids within the C4 and C5 vertebral bodies, and an extradural component causing cord compression. CT showed extensive bony destruction at both levels. The diagnosis of an intraosseous AVM was confirmed with spinal angiography. The AVM was noted to be fed by branches from the ascending cervical arteries and the vertebral artery. The nidus was draining into the vertebral venous plexus and thence into the jugular vein through the marginal sinus. The patient underwent partial embolization of the AVM. Surgical resection was attempted but found to be unfeasible due to torrential bleeding. A 360-degree stabilization along with decompressive laminectomies was performed, resulting in clinical improvement and disease stabilization at one year follow-up. The case and its management dilemmas are discussed in light of a brief literature review.
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  • 文章类型: Journal Article
    关节突骨折通常与临床观察到的颈椎关节脱位(CFDs)相关;然而,迄今为止,只有一项实验研究,使用功能性脊柱单位(FSU),系统地产生了伴随小平面骨折的CFD。先前已经显示了轴向压缩和牵引在与FSU中的CFD相关的椎间运动下对颈椎小平面的机械响应的作用。在屈曲载荷下的下颈椎多节段标本中未证明相同(假定为与CFD相关的局部损伤矢量)。
    本研究调查了13个C5-C7标本(67±13年,6男性)在非破坏性约束屈曲期间,与五个轴向条件中的每一个叠加:(1)50N压缩(模拟头部的重量);(2-4)300、500和1000N压缩(模拟在头部第一冲击和/或外部施加的压缩力之前由颈部肌肉支撑产生的椎间压缩的频谱);和,(5)2mm的C6/C7牵张(模拟在颈椎因头部重量而惯性加载期间存在的椎间牵张)。线性混合效应模型(α=0.05)评估了轴向条件的影响。
    增加的椎间压缩叠加在屈曲旋转上,导致小平面表面应变增加(相对于中性的估计平均差范围:最大主=77至110με,最小主=126至293με,最大剪切=203至375με)和双侧下C6小平面相对于C6椎体的角偏转(相对于中性的估计平均差范围=0.59°至1.47°)。
    这些发现表明,通过小平面关节增加了小平面接合和更高的载荷传递,在压缩轴向条件下,小面断裂的可能性更高。
    UNASSIGNED: Facet fractures are frequently associated with clinically observed cervical facet dislocations (CFDs); however, to date there has only been one experimental study, using functional spinal units (FSUs), which has systematically produced CFD with concomitant facet fracture. The role of axial compression and distraction on the mechanical response of the cervical facets under intervertebral motions associated with CFD in FSUs has previously been shown. The same has not been demonstrated in multi-segment lower cervical spine specimens under flexion loading (postulated to be the local injury vector associated with CFD).
    UNASSIGNED: This study investigated the mechanical response of the bilateral inferior C6 facets of thirteen C5-C7 specimens (67±13 yr, 6 male) during non-destructive constrained flexion, superimposed with each of five axial conditions: (1) 50 N compression (simulating weight of the head); (2-4) 300, 500, and 1000 N compression (simulating the spectrum of intervertebral compression resulting from neck muscle bracing prior to head-first impact and/or externally applied compressive forces); and, (5) 2 mm of C6/C7 distraction (simulating the intervertebral distraction present during inertial loading of the cervical spine by the weight of the head). Linear mixed-effects models (α = 0.05) assessed the effect of axial condition.
    UNASSIGNED: Increasing amounts of intervertebral compression superimposed on flexion rotations, resulted in increased facet surface strains (range of estimated mean difference relative to Neutral: maximum principal = 77 to 110 με, minimum principal = 126 to 293 με, maximum shear = 203 to 375 με) and angular deflection of the bilateral inferior C6 facets relative to the C6 vertebral body (range of estimated mean difference relative to Neutral = 0.59° to 1.47°).
    UNASSIGNED: These findings suggest increased facet engagement and higher load transfer through the facet joint, and potentially a higher likelihood of facet fracture under the compressed axial conditions.
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    文章类型: Journal Article
    我们评估了患有中风的西非土著人群的颈动脉和椎动脉粥样硬化的特征。
    在2014年01月至2017年08月招募的3778例中风患者中,有1070例(28.3%)接受了B型超声对颈动脉和椎动脉的评估。使用多部位技术测量双侧颈动脉和椎体内中膜厚度(IMT),并确定斑块频率。进行了中风类型和血管之间的描述性和比较分析。
    有809例(75.6%)缺血性卒中患者。研究人群中内膜-中膜增厚的患病率为84.0%(898/1070)[95%CI:81.7-86.1],缺血性卒中(688/809,85.0%)[95%CI:82.4-87.3]高于出血性卒中组(211/261,80.8%)[95%CI:75.6-85.2]。斑块的总体患病率为26.1%[95%CI:23.5-28.8],在缺血性中风中也发现高于出血性中风(29.8%[95%CI:26.7-33.0]vs.14.6%[95%CI:10.8-19.4],p<0.05)。平均IMT(颈动脉:2.01+1.33毫米;椎骨:0.96+0.54毫米,p<0.001)和斑块的患病率(颈动脉:8.8%;椎骨:1.7%,p<0.001)在颈动脉中高于椎动脉。年龄,高血压,正规教育水平,吸烟史,月平均收入,高血压和卒中家族史与缺血性卒中患者颈动脉内中膜增厚相关(均P<0.05),而高血压家族史,糖尿病,和正规教育水平与出血性卒中患者颈动脉内中膜增厚独立相关(均p<0.05)。CVRF均未显示与两种卒中类型的颈动脉和椎动脉中斑块的存在独立关联。
    我们队列中的一位中风患者有动脉粥样硬化斑块,与出血性患者相比,缺血性患者有这种负担的可能性是后者的两倍,颈动脉粥样硬化是椎骨动脉粥样硬化的五倍。
    UNASSIGNED: We evaluated the characteristics of carotid and vertebral atherosclerosis in indigenous West Africans with stroke.
    UNASSIGNED: Of the 3778stroke patients recruited between 01/2014 and 08/2017, 1070 (28.3%) received carotid and vertebral artery evaluation with B-mode Ultrasound. Carotid and vertebral intima-media thickness (IMT) using multiple site technique were measured bilaterally and plaque frequency was determined. Descriptive and comparative analyses between stroke types and vessels were carried out.
    UNASSIGNED: There were 809 (75.6%) patients with ischemic stroke. The prevalence of intima-media thickening in the study population was 84.0% (898/1070) [95% CI: 81.7-86.1], being higher in the ischemic stroke (688/809, 85.0%) [95% CI: 82.4-87.3] than in the hemorrhagic stroke group (211/261, 80.8%) [95% CI: 75.6-85.2]. Overall prevalence of plaques which was 26.1% [95% CI: 23.5-28.8], was found also to be higher in ischemic than hemorrhagic stroke (29.8%[95% CI: 26.7-33.0] vs. 14.6% [95% CI: 10.8-19.4], p < 0.05). The mean IMT (carotids: 2.01+1.33 mm; vertebrals: 0.96+0.54mm, p<0.001) and prevalence of plaques (carotids: 8.8%; vertebrals: 1.7%,p<0.001) were higher in carotid than vertebral arteries. Age, hypertension, level of formal education, history of smoking, average monthly income, and family histories of hypertension and stroke were associated with intima-media thickening in the carotids (all p< 0.05) in the ischemic stroke patients while family history of hypertension, diabetes mellitus, and level of formal education were independently associated with intima-media thickening in the carotids (all p< 0.05) in the hemorrhagic stroke patients. No CVRF showed an independent association with the presence of plaque in the carotid and vertebral arteries both stroke types.
    UNASSIGNED: One off our stroke patients in our cohort had atherosclerotic plaques, with ischemic patients being twice as likely to have this burden compared to hemorrhagic patients, and carotid atherosclerosis being five times as frequent as vertebral atherosclerosis.
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  • 文章类型: Journal Article
    该研究的目的是评估椎体后凸成形术和可膨胀的椎体内植入物在治疗创伤性椎体压缩性骨折中的作用。
    这是一个系统的回顾。
    根据PRISMA指南,在PubMed/MEDLINE数据库中进行了关于脊柱后凸成形术和可扩张椎管内植入物治疗创伤性胸腰椎骨折的文献检索。
    共筛选了611条记录。总的来说,51项研究涉及椎体后凸成形术治疗的创伤性椎体骨折;然而,其中,仅选择了针对创伤性爆裂骨折的研究,导致12项研究:10项关于椎体后凸成形术,2项关于武装椎体后凸成形术。在所有研究中,临床和功能参数有统计学上的显着改善,恢复椎体高度,减少椎体和节段后凸。总的来说,在整个随访期间,只有身高的残余损失和后凸的轻微增加,虽然并发症主要是水泥渗漏,都没有临床反应.
    在讨论之后,我们讨论直接和间接减少的概念,椎体后凸成形术与椎弓根固定的关联,可扩张的椎管内植入物的潜在优势,以及椎体后凸成形术中的椎体填充类型,结论是,椎体后凸成形术作为一种后路经皮椎弓根入路重建爆裂骨折前柱的方法显示出良好的效果。它允许重建椎体更接近其原始解剖结构,以微创和安全的方式进行,这提供了在中长期维持的临床功能和影像学改善。
    UNASSIGNED: The aim of the study was to assess the role of kyphoplasty and expandable intravertebral implants in the treatment of traumatic vertebral compression fractures.
    UNASSIGNED: This is a systematic review.
    UNASSIGNED: A bibliographic search was carried out in the PubMed/MEDLINE database according to PRISMA guidelines regarding kyphoplasty and expandable intravertebral implants in the treatment of traumatic thoracolumbar vertebral fractures.
    UNASSIGNED: A total of 611 records were screened. In total, 51 studies were obtained referring to traumatic vertebral fractures treated with kyphoplasty; however, of these, only studies addressing traumatic burst fractures were selected, resulting in 12 studies: 10 about kyphoplasty and 2 regarding armed kyphoplasty. In all studies, there was a statistically significant improvement in clinical and functional parameters, restoration of vertebral height and decreasing of vertebral and segmental kyphosis. Overall, there was only a residual loss of height and a slight increase in kyphosis throughout the follow-up period, while complications consisted essentially of cement leakage, all with no clinical repercussions.
    UNASSIGNED: After the discussion, where we address the concepts of direct and indirect reduction, the association of kyphoplasty with pedicle fixation, the potential advantages of expandable intravertebral implants, as well as the vertebral body type of filling in kyphoplasty, it is concluded that kyphoplasty demonstrates favorable outcomes as a method of posterior percutaneous transpedicular access for reconstruction of the anterior column in burst fractures. It allows for the reconstruction of the vertebral body closer to its original anatomy, carried out in a minimally invasive and safe way, which provides a clinical-functional and imaging improvement maintained at the medium-long term.
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  • 文章类型: Journal Article
    背景:眼部缺血综合征(OIS)是一种罕见的动脉粥样硬化性颈动脉狭窄,可导致永久性视力丧失。由于缺乏意识,这种严重致残综合征仍未得到诊断和治疗;特别是因为它需要加速多学科护理。由于脑血管疾病的患病率增加,早期诊断和治疗的相关性正在增加。
    方法:非动脉炎性OIS介入治疗后的长期视觉和脑血管结局仍未得到很好的描述,这是这篇简明综述的目的。我们进行了PubMed搜索,以包括2002年至2023年之间的所有英语出版物(队列研究和案例报告)。
    结果:共有33项研究(479例患者)报告了颈动脉内膜切除术治疗OIS的结果(CEA,304名患者,19项研究),和颈动脉支架置入术(CAS,175名患者,14项研究)。447例(93.3%)患者的视力结果改善或没有恶化。未报告围手术期中风。很少有视觉症状恶化(35例患者,7.3%);它们发生在继发于眼部灌注不足(3例)的术后即刻,以及由于全身性动脉粥样硬化疾病的进展而在术后后期。据报道,1例患者(0.21%)因CEA后复发性狭窄而出现症状复发,这是与CAS成功管理。这些研究都没有报道经颈动脉血运重建(TCAR)的结果,长期手术结果或卒中发生率。
    结论:OIS仍然是一种未被诊断的疾病。早期诊断和及时治疗对于OIS症状的逆转或稳定至关重要。血管外科和眼科服务之间的加速多学科方法对于促进及时治疗和优化结果是必要的。如果早期诊断,CEA和CAS都与视觉改善有关,和预防进行性视力丧失。
    BACKGROUND: Ocular ischemic syndrome (OIS) is a rare presentation of atherosclerotic carotid artery stenosis that can result in permanent visual loss. This severely disabling syndrome remains under diagnosed and undertreated due to lack of awareness; especially since it requires expedited multidisciplinary care. The relevance of early diagnosis and treatment is increasing due to an increasing prevalence of cerebrovascular disease.
    METHODS: The long-term visual and cerebrovascular outcomes following intervention for nonarteritic OIS, remain poorly described and were the objective of this concise review. We conducted a PubMed search to include all English language publications (cohort studies and case reports) between 2002 and 2023.
    RESULTS: A total of 33 studies (479 patients) report the outcomes of treatment of OIS with carotid endarterectomy (CEA, 304 patients, 19 studies), and carotid artery stenting (CAS, 175 patients, 14 studies). Visual outcomes were improved or did not worsen in 447 patients (93.3%). No periprocedural stroke was reported. Worsening visual symptoms were rare (35 patients, 7.3%); they occurred in the immediate postoperative period secondary to ocular hypoperfusion (3 patients) and in the late postoperative period due to progression of systemic atherosclerotic disease. Symptomatic recurrence due to recurrent stenosis after CEA was reported in 1 patient (0.21%); this was managed successfully with CAS. None of these studies report the results of transcarotid artery revascularization, the long-term operative outcome or stroke rate.
    CONCLUSIONS: OIS remains to be an underdiagnosed condition. Early diagnosis and prompt treatment are crucial in reversal or stabilization of OIS symptoms. An expedited multidisciplinary approach between vascular surgery and ophthalmology services is necessary to facilitate timely treatment and optimize outcome. If diagnosed early, both CEA and CAS have been associated with visual improvement and prevention of progressive visual loss.
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  • 文章类型: Journal Article
    目的:纳入椎体心脏评分(VHS)和,最近,在影像学评估中纳入椎体左心房大小(VLAS)已成为识别隐匿性心脏病犬的重要筛查工具.最近的几篇论文表明,VHS参考范围存在品种间的差异。我们的假设是,微型雪纳瑞的VHS参考范围也将更高。
    方法:在2022年3月1日至2023年2月28日期间,对IDEXX远程医疗顾问的电子病历进行了搜索,以寻找接受胸部X光检查的小型雪纳犬。
    方法:如果狗进行了3次胸片检查,并且没有检测到心肺疾病的证据,则将它们包括在内。排除放射学研究不完整或心脏或心外疾病的狗。VHS和VLAS测量由2位相互独立的认证心脏病专家进行。
    结果:共获得1,000张X射线照片,其中272张被纳入研究。该队列中VHS的总体范围为9.68至12.07,中位数为10.9。对于VLAS测量,记录的范围为1.71~2.4,中位数为2.0.
    结论:经证实,无心脏疾病的小型雪纳犬的VHS高于犬的参考范围。
    OBJECTIVE: The inclusion of vertebral heart score (VHS) and, more recently, the inclusion of the vertebral left atrial size (VLAS) in radiographic evaluation have become important screening tools for identifying dogs with occult cardiac disease. Several recent papers have shown there are interbreed variations in the VHS reference range. Our hypothesis is that the Miniature Schnauzer would also have a higher reference range for its VHS.
    METHODS: The electronic medical records of IDEXX Telemedicine Consultants were searched for Miniature Schnauzers undergoing thoracic radiographs between March 1, 2022, and February 28, 2023.
    METHODS: Dogs were included if they had 3 view thoracic radiographs performed and no evidence of cardiopulmonary disease was detected. Dogs with incomplete radiographic studies or cardiac or extracardiac disease were excluded. The VHS and VLAS measurements were performed by 2 board-certified cardiologists independent of one another.
    RESULTS: A total of 1,000 radiographs were obtained of which 272 were included for the study. The overall range for the VHS in this cohort was 9.68 to 12.07 with a median of 10.9. For VLAS measurements, a range of 1.71 to 2.4 was documented with a median of 2.0.
    CONCLUSIONS: The VHS for Miniature Schnauzers without cardiac disease was confirmed to be higher than the canine reference range.
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  • 文章类型: Case Reports
    胸腰椎容易发生椎体压缩性骨折(VCFs)。一种称为屈曲压缩的损伤机制是导致胸腰椎压缩性骨折的原因。通常,该机制影响椎体前部和前部的纵韧带作为第一组件。疼痛是首要的症状,这里我们介绍一个34岁男性的病例报告,带着背痛的抱怨来到医院,呼吸困难,随后发生道路交通事故(RTA)。进行了MRI和X射线检查。该患者被诊断为右第四和第五肋骨的前外侧和第六肋骨的后外侧骨折,急性前楔形压缩L1椎体骨折,和双侧轻微气胸和血胸。对患者进行D12-L2水平的减压和脊柱融合术后手术治疗。使用的结果是Oswestry腰背残疾问卷,数字疼痛评定量表,和手动肌肉测试(MMT)。本病例报告规定了理疗康复方案,主要集中在呼吸练习等技术上,上肢和下肢加强,躯干和盆底肌肉加强。
    The thoracolumbar spine is prone to vertebral compression fractures (VCFs). An injury mechanism known as flexion compression is responsible for thoracolumbar spine compression fractures. Usually, this mechanism affects the longitudinal ligament at the front and the front part of the vertebral body as the first components. Pain is the first and foremost symptom; here we present a case report of a 34-year-old male, who came to the hospital with complaints of back pain, and difficulty in breathing followed by a road traffic accident (RTA). MRI and X-ray investigations were done. The patient was diagnosed with a fracture of the anterolateral aspect of the right fourth and fifth ribs and posterolateral aspect of the sixth rib, acute anterior wedge compression fracture of the L1 vertebra, and bilateral minimal pneumothorax and haemothorax. The patient was managed surgically with post-decompression and spinal fusion at the D12-L2 level. The outcomes used were the Oswestry Low-Back Disability Questionnaire, the numerical pain rating scale, and Manual Muscle Testing (MMT). This case report specifies the physiotherapeutic rehabilitation protocol, mainly focusing on techniques like breathing exercises, and upper limb and lower limb strengthening along with trunk and pelvic floor muscles strengthening.
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  • 文章类型: Journal Article
    脊柱原发性恶性骨肿瘤极为罕见,孤立性骨浆细胞瘤(SBP)约占所有病例的30%。放射学评估对于定位SBP和排除多发性骨髓瘤(MM)的诊断至关重要。类似“微型大脑”的成像特征似乎是SBP的独特之处。伴有相邻椎间盘间隙受累的椎体病变通常提示脊柱感染。而SBP参与的潜力往往被忽视。我们介绍了一例61岁的女性SBP,表现出胸腰椎破坏和相邻椎间盘间隙受累。由于腰背痛向腹股沟区辐射,患者在我们的医疗中心寻求治疗。放射学发现涉及椎间盘的溶骨性病变,很难区分肿瘤和炎症。椎体病变的活检证实了SBP的诊断,这得到了实验室结果的进一步支持。诊断后,病人接受了放疗,接受4000Gy的总剂量,缓解了她的症状.我们还提供了有关椎间盘受累的SBP的全面文献综述,以帮助临床和放射学诊断。
    Primary malignant bone tumors of the spine are exceedingly rare, with solitary bone plasmacytoma (SBP) representing approximately 30% of all cases. Radiological assessments are crucial for localizing SBP and for ruling out a diagnosis of multiple myeloma (MM). Imaging features resembling a \"mini-brain\" appear to be distinctive for SBP. Vertebral lesions accompanied by adjacent disc space involvement typically suggest spinal infections, while the potential for SBP involvement is often overlooked. We present a case of a 61-year-old female with SBP who exhibited thoraco-lumbar spine destruction and adjacent disc space involvement. The patient sought treatment at our medical center due to lumbodorsal pain radiating bilaterally to the inguinal regions. Radiological findings revealed an osteolytic lesion involving the intervertebral disc, making it challenging to distinguish between tumor and inflammation. A biopsy of the vertebral lesion confirmed the diagnosis of SBP, which was further supported by laboratory results. Post-diagnosis, the patient underwent radiotherapy, receiving a total dose of 4000 Gy, which alleviated her symptoms. We also provide a comprehensive literature review on SBP with disc involvement to aid both clinical and radiological diagnoses.
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  • 文章类型: Journal Article
    随着疾病的进展,二尖瓣疾病(MVD)患者的左心房大小(LAS)增加。椎体左心房大小(VLAS),改良的椎骨左心房大小(M-VLAS),和X线摄影左心房尺寸(RLAD)是报道的评估狗X线照片上的LAS的方法。所有这些方法将LAS转换为椎骨单位。胸入口(TI)已被用作测量不同阶段MVD犬心脏轮廓的可靠参考点。这项研究的目的是评估使用TI作为参考在右胸部X射线上测量狗LAS的临床实用性,并确定它是否可以区分不同MVD阶段的狗。LAS除以TI以获得胸廓入口左房评分(TILAS)。这是一项回顾性观察研究,包括135只明显健康的狗,用四种不同的方法评估他们的LAS:VLAS,M-VLAS,RLAD,和Tilas。从普通人群中选择36只狗,并与不同MVD阶段的100只狗进行比较。对照犬和MVD犬的TILAS差异显著,随疾病分期而增加:对照犬0.51±0.08,B10.57±0.14,B20.75±0.13和C0.84±0.18。VLAS,M-VLAS,RLAD也随着疾病的进展而增加,如以前的研究所示。TILAS区分MVD犬心脏扩大的准确性与VLAS相当,M-VLAS,和RLAD(AUC0.91vs.分别为0.93、0.90和0.94)。TILAS>0.8可以识别继发于MVD的心脏扩大的狗。
    The left atrial size increases (LAS) in patients with mitral valve disease (MVD) as the disease progresses. The vertebral left atrial size (VLAS), the modified-vertebral left atrial size (M-VLAS), and the radiographic left atrial dimension (RLAD) are methods reported to assess LAS on dogs\' radiographs. All these methods transform the LAS into vertebral units. The thoracic inlet (TI) has been used as a reliable reference point to measure the cardiac silhouette of dogs with MVD in different stages. The objective of this study was to assess the clinical utility of measuring a dog LAS on right thoracic X-rays using the TI as a reference and determine whether it could differentiate dogs in different MVD stages. LAS was divided by the TI to obtain the thoracic inlet left atrial score (TILAS). This was a retrospective observational study including 135 apparently healthy dogs performed to assess their LAS with four different methods: VLAS, M-VLAS, RLAD, and TILAS. Thirty-six dogs from the general population were selected and compared to 100 dogs in different MVD stages. The TILAS was significantly different between the control dogs and MVD dogs, increasing with the disease stage: control dogs 0.51 ± 0.08, B1 0.57 ± 0.14, B2 0.75 ± 0.13, and C 0.84 ± 0.18. VLAS, M-VLAS, and RLAD also increased as the disease progressed, as shown in previous studies. The TILAS accuracy to distinguish MVD dogs with cardiac enlargement was comparable to VLAS, M-VLAS, and RLAD (AUC 0.91 vs. 0.93, 0.90, and 0.94 respectively). A TILAS > 0.8 can identify dogs with cardiac enlargement secondary to MVD.
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  • 文章类型: Journal Article
    目的:外伤性椎动脉损伤(VAI)的治疗仍在争论中。目前的共识是保留对高级别损伤的手术或血管内治疗,以预防中风。我们试图评估创伤性VAI后影响后颅窝卒中结局的因素。
    方法:从2013年至2019年,在1级创伤中心对18岁以上诊断为VAI的患者的前瞻性维持的PROOVIT创伤登记进行了搜索。患者人口统计学,损伤类型,介绍的时间,Biffl脑血管损伤分级评分,医疗管理,程序性干预,并对卒中结局进行分析.
    结果:在进入PROOVIT注册的14,323例患者中,发现66例创伤患者的椎动脉损伤。主要机制是钝性损伤(91.5%vs8.5%,钝vs.穿透)。9例患者在影像学上可见症状性同侧后循环中风。卒中组和非卒中组的平均Biffl分级相似(2.0vs.1.5;p=0.39)。卒中和非卒中组之间的平均ISS也相似(9.0vs.14.0;p=0.35)。中风组的所有9名患者在出现后平均21.2小时内对其梗塞进行了MR成像验证。在中风组中,1例患者接受了诊断性血管造影,但未进行干预。在非中风组中,所有患者均仅接受内科治疗,均未接受椎动脉介入治疗.在平均14.5个月的随访中,没有患者出现新的神经功能缺损.
    结论:根据Biffl分级和ISS的VAI严重程度与VAI后出现的缺血性卒中无关。在该创伤人群中,无论Biffl和ISS分期如何,VAI的医疗管理似乎都是安全的。与栓塞性卒中相关的神经系统变化在介绍时得到了普遍的重视。保守的医疗管理足以防止继发性神经功能缺损,而与前兆椎骨损伤无关。
    BACKGROUND: Management of traumatic vertebral artery injury (VAI) remains under debate. Current consensus reserves surgical or endovascular management for high-grade injury in order to prevent stroke. We sought to evaluate the factors that influence posterior fossa stroke outcomes following traumatic VAI.
    METHODS: A search of the prospectively maintained PROOVIT trauma registry of patients older than 18 years of age with a diagnosis of VAI was performed at a level 1 trauma center from 2013 to 2019. Patient demographics, type of injury, the timing of presentation, Biffl Classification of Cerebrovascular Injury Grade score, medical management, procedural interventions, and stroke outcomes were analyzed.
    RESULTS: VAIs were identified in 66 trauma patients were identified out of 14,323 patients entered into the PROOVIT registry. The dominant mechanism was blunt injury (91.5% vs. 8.5%, blunt versus penetrating). Nine patients presented with symptomatic ipsilateral posterior circulation strokes visible on imaging. The average Biffl classification grade was similar between the stroke and nonstroke groups (2.0 vs. 1.5; P = 0.39). The average injury severity score (ISS) between stroke and nonstroke groups was also similar (9.0 vs. 14.0; P = 0.35). All 9 patients in the stroke group had magnetic resonance imaging verification of their infarct within an average of 21.2 hr from presentation. In the stroke group, 1 patient underwent diagnostic angiography but had no intervention. In the nonstroke group, all were treated with medical management alone and none underwent vertebral artery intervention. During a mean follow-up of 14.5 months, no patients experienced a new neurological deficit.
    CONCLUSIONS: The severity of VAI by Biffl grading and ISS are not associated with ischemic stroke at presentation following VAI. Medical management of VAI appears safe regardless of Biffl and ISS staging in this trauma population. Neurological changes related to embolic stroke were generally appreciated on presentation. Conservative medical management was sufficient to protect from secondary neurological deficit regardless of index vertebral injury.
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