卫生设施中疫苗库存管理不足导致疫苗缺货。后者威胁到免疫接种计划的成功。各国使用了各种方法来减少缺货和提高疫苗供应,但我们还没有对这些干预措施进行系统评价.该协议描述了我们将用于评估现有方法改善疫苗库存管理的效果的方法。
我们包括通过同行评审和灰色文献数据库的全面搜索确定的随机和非随机研究。我们将搜索PubMed,Cochrane中央控制试验登记册,Embase,WebofScience,PDQ-证据和Scopus。我们还将搜索世界卫生组织(WHO)的网站,全球疫苗和免疫联盟,PATH疫苗资源库和联合国儿童基金会。此外,我们将检索世卫组织国际临床试验注册平台以及纳入研究和相关综述的参考清单.最后,我们计划对纳入的研究进行引文搜索。我们将使用Cochrane推荐的方法来筛选搜索输出,评估研究资格和偏见风险,提取和分析研究结果。我们将使用建议评估等级,开发和评估(GRADE)工具,用于评估干预措施效果的证据的确定性。
我们相信,此次审查的结果将为政策制定者提供有关如何改善疫苗库存管理和疫苗可用性的有价值的信息。当疫苗可用性提高时,那些需要它们的人,尤其是儿童,将充分保护免受疫苗可预防的疾病。
PROSPEROCRD42018092215。
Inadequate vaccine stock management in health facilities leads to vaccine stock-outs. The latter threatens the success of immunisation programmes. Countries have used various approaches to reduce stock-outs and improve vaccine availability, but we are not aware of a systematic review of these interventions. This protocol describes the methods we will use to assess the effects of existing approaches for improving vaccine stock management.
We include randomised and non-randomised studies identified through a compehensive search of peer-reviewed and grey literature databases. We will search PubMed, Cochrane Central Register of Controlled Trials, Embase, Web of Science, PDQ-Evidence and Scopus. We will also search websites of the World Health Organisation (WHO), Global Alliance for Vaccine and Immunisation, PATH Vaccine Resources Library and United Nations Children\'s Fund. In addition, we will search the WHO International Clinical Trials Registry Platform and reference lists of included studies and relevant reviews. Finally, we plan to do a citation search for included studies. We will use Cochrane recommended methods to screen search outputs, assess study eligibility and risk of bias, extract and analyse study results. We will use the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool to assess the certainty of the evidence on the effects of the interventions.
We believe that the findings of this review will serve as valuable information for policy makers on ways to improve vaccine stock management and vaccine availability. When vaccine availability is improved, those who need them, especially children, will be adequately protected from vaccine-preventable diseases.
PROSPERO CRD42018092215.