目的:提出一种薄于10μm的超薄生物羊膜(btAM)作为治疗高度近视黄斑裂孔(MH)的移植物。
方法:这项初步研究包括14名患有与高度近视相关的难治性黄斑裂孔的患者。btAM用作覆盖孔的绷带。最佳矫正视力(BCVA),眼底摄影,比较手术前后的光学相干断层扫描(OCT)。
结果:平均MH大小为865.93±371.72μm,所有MH均实现了解剖闭合。从眼底摄影中,btAM位于MHs的中央和完全位置,但没有明显的视觉掩蔽。平均BCVA1个月,术后3、6个月分别为0.95±0.24、0.92±0.23、0.92±0.23logMAR,分别,与术前BCVA(1.24±0.42logMAR,所有P<0.05)。14人中有10人(71.4%)在OCT上表现出2C闭合模式(正式闭合且无裸露RPE)。
结论:btAM稀释剂显示出良好的解剖学成功,减少了旁凹萎缩或医源性损伤的风险,并缩短了溶解时间。
OBJECTIVE: To propose an
ultrathin biological amniotic membrane (btAM) thinner than 10 μm as the graft to treat highly myopic macular holes (MH).
METHODS: This pilot study included 14 patients affected by refractory macular holes associated with high myopia. btAM was used as a bandage covering the holes. The best-corrected visual acuity (BCVA), fundus photography, and optical coherence tomography (OCT) before and after surgery were compared.
RESULTS: The mean MH size was 865.93 ± 371.72 μm and all the MHs achieved anatomical closure. The btAM located centrally and fully on MHs from fundus photography yet no obvious visual masking was complained. The average BCVA 1 month, 3, and 6 months after surgery were 0.95 ± 0.24, 0.92 ± 0.23, 0.92 ± 0.23 logMAR, respectively, improved significantly compared to pre-operative BCVA (1.24 ± 0.42 logMAR, all P < 0.05). Ten out of 14 (71.4%) exhibited 2C closure patterns (formally closed and no bare RPE) on OCT.
CONCLUSIONS: The btAM thinner showed a favorable anatomical success with less risk of parafoveal atrophy or iatrogenic injuries and shortened the dissolving time.