目的:本研究旨在探讨多囊卵巢综合征(PCOS)患者血清中甲状腺激素的变化及其与胰岛素抵抗的相关性。
方法:这是一项回顾性研究。
方法:纳入84例胰岛素抵抗患者和76例无胰岛素抵抗患者。选择90例无PCOS病史的女性作为健康对照组。
方法:本研究在石家庄市第四医院进行。
方法:在月经周期的第3-5天从每组收集血样,和他们的三碘甲状腺原氨酸(T3),分析并比较各组间甲状腺素(T4)和促甲状腺激素(TSH)水平。
结果:我们研究了PCOS患者血清甲状腺激素的变化及其与胰岛素抵抗的相关性。我们发现血清T3和T4水平明显下降,而与健康对照组相比,PCOS患者的TSH水平显著升高。此外,我们发现,与无胰岛素抵抗的PCOS参与者相比,有胰岛素抵抗的患者的血清T3和T4水平显著较低,而TSH水平较高.
结论:本研究为回顾性单中心研究,有选择偏见,信息偏差,和混杂变量可能会影响结论的准确性和可靠性。
结论:胰岛素抵抗与血清T3、T4呈负相关,与TSH水平呈正相关。我们的结果与血清T3,T4和TSH水平建立了联合测试模型,用于PCOS女性胰岛素抵抗的临床诊断。
OBJECTIVE: This study aimed to investigate the changes in thyroid hormones in the serum of patients with polycystic ovary syndrome (PCOS) and their correlation with insulin resistance.
METHODS: This is a retrospective study.
METHODS: 84 patients having insulin resistance and 76 patients without insulin resistance were included. 90 women without history of PCOS were selected as a healthy control group.
METHODS: This study was conducted at Shijiazhuang Fourth Hospital.
METHODS: Blood samples were collected from each group on days 3-5 of their menstrual cycle, and their triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) levels were analyzed and compared between groups.
RESULTS: We investigated the changes of serum thyroid hormones in patients with PCOS and their correlation with insulin resistance. We found that serum levels of T3 and T4 were significantly decreased, while TSH levels were significantly increased in PCOS patients compared with HCs. Moreover, we found that patients with insulin resistance had significantly lower levels of serum T3 and T4 and higher levels of TSH compared to those PCOS participants without insulin resistance.
CONCLUSIONS: This study was a retrospective and single-center study, which had selection bias, information bias, and confounding variables may affect the accuracy and reliability of the conclusion.
CONCLUSIONS: Insulin resistance negative correlates with their serum T3, T4, and positive correlates with their TSH levels. Our results develop a combined test model with the serum T3, T4, and TSH levels for the clinical diagnosis of insulin resistance in PCOS women.