■阿霉素(DOX)作为强效化疗剂武器库中的基石出现。然而,DOX的临床部署因其诱发严重心脏毒性作用的倾向而受损,最终导致心力衰竭和其他相应的疾病。作为回应,近几十年来,一系列战略经历了严格的探索,所有这些都旨在减轻DOX的心脏毒性影响。将DOX封装在脂质或聚合物纳米载体中的出现产生了双重胜利,增强DOX的治疗功效,同时减轻其有害副作用。
■最近的进步使DOX缀合物的出现成为改善DOX诱导的心脏毒性的特别有利的途径。这些缀合物需要DOX通过物理或化学键与小型天然或合成部分融合。聚合物,生物分子,和纳米粒子。这一范围包括影响DOX心脏毒性机制的干预措施,调节细胞摄取和定位,赋予抗氧化性能,或细化细胞靶向。
■DOX结合物作为减轻DOX引起的心脏毒性的令人信服的策略的认可,放大安全裕度和这种备受推崇的化学治疗剂的治疗概况。在这个范围内,DOX缀合物作为永久追求改善化疗诱导的心脏妥协的希望灯塔。
UNASSIGNED: Doxorubicin (DOX) emerges as a cornerstone in the arsenal of potent chemotherapeutic agents. Yet, the clinical deployment of DOX is tarnished by its proclivity to induce severe cardiotoxic effects, culminating in heart failure and other consequential morbidities. In response, a panoply of strategies has undergone rigorous exploration over recent decades, all aimed at attenuating DOX\'s cardiotoxic impact. The advent of encapsulating DOX within lipidic or polymeric nanocarriers has yielded a dual triumph, augmenting DOX\'s therapeutic efficacy while mitigating its deleterious side effects.
UNASSIGNED: Recent strides have spotlighted the emergence of DOX conjugates as particularly auspicious avenues for ameliorating DOX-induced cardiotoxicity. These conjugates entail the fusion of DOX through physical or chemical bonds with diminutive natural or synthetic moieties, polymers, biomolecules, and nanoparticles. This spectrum encompasses interventions that impinge upon DOX\'s cardiotoxic mechanism, modulate cellular uptake and localization, confer antioxidative properties, or refine cellular targeting.
UNASSIGNED: The endorsement of DOX conjugates as a compelling stratagem to mitigate DOX-induced cardiotoxicity resounds from this exegesis, amplifying safety margins and the therapeutic profile of this venerated chemotherapeutic agent. Within this ambit, DOX conjugates stand as a beacon of promise in the perpetual pursuit of refining chemotherapy-induced cardiac compromise.