PDF(Pubmed)
Abstract：
FLASH radiotherapy (FLASH-RT) is a novel radiotherapy approach based on the use of ultra-high dose radiation to treat malignant cells. Although tumours can be reduced or eradicated using radiotherapy, toxicities induced by radiation can compromise healthy tissues. The FLASH effect is the observation that treatment delivered at an ultra-high dose rate is able to reduce adverse toxicities present at conventional dose rates. While this novel technique may provide a turning point for clinical practice, the exact mechanisms underlying the causes or influences of the FLASH effect are not fully understood. The study presented here uses data collected from 41 experimental investigations (published before March 2024) of the FLASH effect. Searchable databases were constructed to contain the outcomes of the various experiments in addition to values of beam parameters that may have a bearing on the FLASH effect. An in-depth review of the impact of the key beam parameters on the results of the experiments was carried out. Correlations between parameter values and experimental outcomes were studied. Pulse Dose Rate had positive correlations with almost all end points, suggesting viability of FLASH-RT as a new modality of radiotherapy. The collective results of this systematic review study suggest that beam parameter qualities from both FLASH and conventional radiotherapy can be valuable for tissue sparing and effective tumour treatment.
摘要：
FLASH放射治疗(FLASH-RT)是一种利用超高剂量辐射治疗恶性细胞的新型放射治疗方法。虽然使用放疗可以减少或根除肿瘤，辐射引起的毒性会损害健康组织。FLASH效应是以超高剂量率递送的治疗能够减少以常规剂量率存在的不良毒性的观察结果。虽然这项新技术可能为临床实践提供一个转折点，FLASH效应的原因或影响的确切机制尚不完全清楚。此处介绍的研究使用了从41个FLASH效应实验研究（在2024年3月之前发布）中收集的数据。构建了可搜索的数据库，以包含各种实验的结果以及可能与FLASH效应有关的光束参数值。对关键梁参数对实验结果的影响进行了深入的审查。研究了参数值与实验结果之间的相关性。脉搏剂量率与几乎所有终点呈正相关，提示FLASH-RT作为一种新的放疗方式的可行性。这项系统综述研究的集体结果表明，FLASH和常规放射疗法的光束参数质量对于组织保留和有效的肿瘤治疗都是有价值的。
