阿尔茨海默病(Alzheimer\'sdisease,AD)是世界范围内最常见且不可逆的神经退行性疾病。虽然这种快速进展和多方面疾病背后的确切机制仍然未知,现有疗法的许多缺点是普遍存在的,需要有效的替代治疗方法。鉴于对有效AD治疗的需求不断增加,许多报道表明,四氢异喹啉(THIQ)是各种临床药物分子中的一种有价值的支架,并且由于其显着的神经保护作用,在治疗AD方面具有很有希望的潜力。抗炎,和抗氧化特性通过几种靶向改变的信号通路的机制。因此,这篇综述全面概述了THIQ衍生物在AD治疗中的潜在应用,以及在赋予这些前瞻性治疗药物作用方面面临的挑战.该评论强调了许多THIQ衍生物,包括Dauricine,jatrorrhizine,1MeTIQ,还有Thicapa,近年来已纳入AD研究。随后,这篇综述的一个专门部分简要讨论了多靶点疗法的新兴潜在益处,这取决于它们与替代疗法整合的能力。最终,这篇综述阐述了开发有效治疗AD的治疗药物所面临的挑战和未来的建议。实质上,这篇全面综述中对THIQ衍生物的有价值的研究见解将为未来研究开发用于AD研究的有效治疗药物提供重要参考.
Alzheimer\'s disease (AD) is the most common and irreversible neurodegenerative disorder worldwide. While the precise mechanism behind this rapid progression and multifaceted disease remains unknown, the numerous drawbacks of the available therapies are prevalent, necessitating effective alternative treatment methods. In view of the rising demand for effective AD treatment, numerous reports have shown that tetrahydroisoquinoline (THIQ) is a valuable scaffold in various clinical medicinal molecules and has a promising potential as a therapeutic agent in treating AD due to its significant neuroprotective, anti-inflammatory, and antioxidative properties via several mechanisms that target the altered signaling pathways. Therefore, this review comprehensively outlines the potential application of THIQ derivatives in AD treatment and the challenges in imparting the action of these prospective therapeutic agents. The review emphasizes a number of THIQ derivatives, including Dauricine, jatrorrhizine, 1MeTIQ, and THICAPA, that have been incorporated in AD studies in recent years. Subsequently, a dedicated section of the review briefly discusses the emerging potential benefits of multi-target therapeutics, which lie in their ability to be integrated with alternative therapeutics. Eventually, this review elaborates on the rising challenges and future recommendations for the development of therapeutic drug agents to treat AD effectively. In essence, the valuable research insights of THIQ derivatives presented in this comprehensive review would serve as an integral reference for future studies to develop potent therapeutic drugs for AD research.