Abstract：
Self-assembled supermolecular hydrogels of therapeutic agents without structural modification are of great significance in biomedical applications. Nevertheless, the complex conformations and elusive interactions of therapeutic molecules limit the controlled assembly of hydrogels. Molecules at the interface might have different arrangements and assemblies compared to those in bulk aqueous solution, which could potentially alter the selectivity of supramolecular polymorphs. However, this effect is still not well understood. Here, we demonstrate the interface-induced self-assembly of fibers for hydrogels, which is distinct from the spherical aggregates in the bulk aqueous solution, using cephradine (CEP) as a model compound. This phenomenon is caused by the packing of anisotropic molecules at the interface, and it can be applied to control the supramolecular polymorphism for the direct self-assembly of hydrogels of therapeutic agents. The interface-induced hydrogel exhibits a high degree of adjustable release and a long-acting bactericidal effect.
摘要：
未经结构修饰的治疗剂的自组装超分子水凝胶在生物医学应用中具有重要意义。然而，治疗分子的复杂构象和难以捉摸的相互作用限制了水凝胶的受控组装。与散装水溶液中的分子相比，界面处的分子可能具有不同的排列和组装。这可能会改变超分子多晶型物的选择性。然而,这种影响仍然没有得到很好的理解。这里,我们展示了用于水凝胶的界面诱导的纤维自组装，这与本体水溶液中的球形聚集体不同，使用头孢拉定（CEP）作为模型化合物。这种现象是由各向异性分子在界面处堆积引起的，它可用于控制超分子多态性，以直接自组装治疗剂的水凝胶。界面诱导的水凝胶表现出高度的可调节释放和长效杀菌效果。
