我们报告了一个涉及天鹅的疾病和死亡事件,密封件,2020年底,英国野生动物康复中心的一只狐狸。五只天鹅在圈养期间感染了高致病性禽流感病毒。随后,5只海豹和一只狐狸在临床疾病发作后死亡(或被安乐死)。回顾性确定禽源甲型流感病毒H5N8亚型为疾病原因。海豹感染表现为癫痫发作,以及对死后样本的免疫组织化学和分子测试检测到病毒产物的神经系统分布。狐狸突然食欲不振,一夜之间死亡,死后组织显示病毒产物的神经系统和呼吸道分布。活病毒是从天鹅身上分离出来的,密封件,还有狐狸,并且在哺乳动物来源的病毒序列中检测到单个遗传变化作为潜在的适应性突变。事件发生后几周内没有人流感样疾病的报告。
We report a disease and mortality event involving swans, seals, and a fox at a wildlife rehabilitation center in the United Kingdom during late 2020. Five swans had onset of highly pathogenic avian influenza virus infection while in captivity. Subsequently, 5 seals and a fox died (or were euthanized) after onset of clinical disease. Avian-origin influenza A virus subtype H5N8 was retrospectively determined as the cause of disease. Infection in the seals manifested as seizures, and immunohistochemical and molecular testing on postmortem samples detected a neurologic distribution of viral products. The fox died overnight after sudden onset of inappetence, and postmortem tissues revealed neurologic and respiratory distribution of viral products. Live virus was isolated from the swans, seals, and the fox, and a single genetic change was detected as a potential adaptive mutation in the mammalian-derived viral sequences. No human influenza-like illness was reported in the weeks after the event.