大多数肿瘤是由遗传或获得性遗传变化引起的。然而,一部分肿瘤是由病毒感染引起的,包括卡波西肉瘤,鼻咽癌,和其他人。人乳头瘤病毒(HPV)是上皮癌和增生的特别常见原因。疣状表皮发育不良(EDV)是一种罕见的HPV感染,具有特征性的组织病理学特征和独特的HPV亚型谱。我们在这里报告了EDV相关的内分泌肿瘤的独特形式。分析了来自两名患者的七个肿瘤,并显示出高度一致的特征,包括多个聚集的临床病变,多灶性表皮起源,内分泌分化与acrossyringium密切相关,吻合的生长模式,和一个平淡无奇的多孔到基底细胞形态学。迄今为止,对一名患者的临床随访是良性的。这些肿瘤与先前报道的两个病例表现出强烈的相似性,提示这种类型的EDV相关内分泌肿瘤可能是一种罕见但可重复的皮肤附件肿瘤,具有独特的临床病理特征。
Most tumors are caused by inherited or acquired genetic changes. However, a subset of tumors is driven by viral infection including Kaposi sarcoma, nasopharyngeal carcinoma, and others. Human papillomavirus (HPV) is an especially common cause of epithelial cancers and hyperplasias. Epidermodysplasia verruciformis (EDV) is a rare type of HPV infection with characteristic histopathologic features and a unique spectrum of HPV subtypes. We report here a distinctive form of EDV-associated eccrine neoplasia. Seven tumors from two patients were analyzed and show highly uniform features including multiple clustered clinical lesions, multifocal epidermal origin, eccrine differentiation with close association with the acrosyringium, an anastomosing growth pattern, and a bland monotonous poroid-to-basaloid cytomorphology. Clinical follow-up for one patient has been benign to date. These tumors show strong similarity to two previously reported cases, suggesting that this type of EDV-associated eccrine neoplasia may represent a rare but reproducible form of skin adnexal tumor with distinctive clinicopathologic features.